PMID- 21881117
OWN - NLM
STAT- MEDLINE
DCOM- 20111123
LR  - 20171116
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Linking)
VI  - 204
IP  - 7
DP  - 2011 Oct 1
TI  - Protection from arthritis and myositis in a mouse model of acute chikungunya 
      virus disease by bindarit, an inhibitor of monocyte chemotactic protein-1 
      synthesis.
PG  - 1026-30
LID - 10.1093/infdis/jir470 [doi]
AB  - Chikungunya virus (CHIKV) is associated with outbreaks of infectious rheumatic 
      disease in humans. Using a mouse model of CHIKV arthritis and myositis, we show 
      that tumor necrosis factor-alpha, interferon-gamma, and monocyte chemotactic protein 1 
      (MCP-1) were dramatically induced in tissues from infected mice. The same factors 
      were detected in the serum of patients with CHIKV-induced polyarthralgia and 
      polyarthritis, with MCP-1 levels being particularly elevated. Bindarit (MCP 
      inhibitor) treatment ameliorated CHIKV disease in mice. Histological analysis of 
      muscle and joint tissues showed a reduction in inflammatory infiltrate in 
      infected mice treated with bindarit. These results suggest that bindarit may be 
      useful in treating CHIKV-induced arthritides in humans.
FAU - Rulli, Nestor E
AU  - Rulli NE
AD  - Emerging Viruses and Inflammation Research Group, Institute for Glycomics, 
      Griffith University, Gold Coast, Southport, Australia.
FAU - Rolph, Michael S
AU  - Rolph MS
FAU - Srikiatkhachorn, Anon
AU  - Srikiatkhachorn A
FAU - Anantapreecha, Surapee
AU  - Anantapreecha S
FAU - Guglielmotti, Angelo
AU  - Guglielmotti A
FAU - Mahalingam, Suresh
AU  - Mahalingam S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Chemokine CCL2)
RN  - 0 (Indazoles)
RN  - 0 (Propionates)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 82115-62-6 (Interferon-gamma)
RN  - JQ11LH711M (bindarit)
SB  - IM
MH  - Alphavirus Infections/blood/*drug therapy
MH  - Animals
MH  - Arthritis, Infectious/pathology/*prevention & control/virology
MH  - Chemokine CCL2/*antagonists & inhibitors/drug effects/metabolism
MH  - Chikungunya Fever
MH  - *Chikungunya virus
MH  - Humans
MH  - Indazoles/pharmacology/*therapeutic use
MH  - Interferon-gamma/metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Models, Animal
MH  - Myositis/pathology/*prevention & control/virology
MH  - Propionates/pharmacology/*therapeutic use
MH  - Tumor Necrosis Factor-alpha/metabolism
MH  - Viral Load/drug effects
EDAT- 2011/09/02 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/09/02 06:00
PHST- 2011/09/02 06:00 [entrez]
PHST- 2011/09/02 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - jir470 [pii]
AID - 10.1093/infdis/jir470 [doi]
PST - ppublish
SO  - J Infect Dis. 2011 Oct 1;204(7):1026-30. doi: 10.1093/infdis/jir470.