PMID- 21881994
OWN - NLM
STAT- MEDLINE
DCOM- 20130220
LR  - 20211020
IS  - 1437-160X (Electronic)
IS  - 0172-8172 (Linking)
VI  - 32
IP  - 10
DP  - 2012 Oct
TI  - Lower expression of histamine H(4) receptor in synovial tissues from patients with 
      rheumatoid arthritis compared to those with osteoarthritis.
PG  - 3309-13
AB  - The aim of this study is to compare the expression level of histamine H(4) 
      receptor (H(4)R) mRNA in synovial tissues of rheumatoid arthritis (RA) and 
      osteoarthritis (OA) patients, and to study correlation of results with clinical 
      characteristics of patients with RA. Synovial tissues were obtained from 7 RA and 
      7 OA patients undergoing artificial arthroplasty. Serum levels of erythrocyte 
      sedimentation rate, C-reactive protein, matrix metalloproteinase-3 (MMP-3), 
      rheumatoid factors, and cyclic citrullinated peptide antibodies were determined. 
      The expression of H(4)R mRNA in synovial tissues was determined by real-time 
      polymerase chain reaction. Expression of H(1)R and H(4)R mRNA were significantly 
      lower in RA compared with OA patients (P < 0.005), while expression of H(2)R mRNA 
      was comparable in both. While a significant negative correlation was found 
      between H(4)R expression and serum MMP-3 concentration (r = -0.70, P < 0.05), no 
      correlation was found between MMP-3 and H(1)R (r = -0.52) or H(2)R (r = 0.23). 
      This study supports the supposition that H(4)R in synovial tissue may play a role 
      in cartilage and bone destruction by influencing the secretion of MMP-3 in 
      patients with RA.
FAU - Yamaura, Katsunori
AU  - Yamaura K
AD  - Department of Geriatric Pharmacology and Therapeutics, Graduate School of 
      Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 
      260-8675, Japan. yamaura@p.chiba-u.ac.jp
FAU - Oda, Manabu
AU  - Oda M
FAU - Suzuki, Masahiko
AU  - Suzuki M
FAU - Ueno, Koichi
AU  - Ueno K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110901
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
RN  - 0 (HRH4 protein, human)
RN  - 0 (Peptides, Cyclic)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - 0 (Receptors, Histamine)
RN  - 0 (Receptors, Histamine H1)
RN  - 0 (Receptors, Histamine H2)
RN  - 0 (Receptors, Histamine H4)
RN  - 0 (cyclic citrullinated peptide)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Aged
MH  - Arthritis, Rheumatoid/blood/*genetics/immunology
MH  - Autoantibodies/blood
MH  - Biomarkers/blood
MH  - C-Reactive Protein/analysis
MH  - Down-Regulation
MH  - Female
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 3/blood
MH  - Middle Aged
MH  - Osteoarthritis/blood/*genetics/immunology
MH  - Peptides, Cyclic/immunology
MH  - RNA, Messenger/analysis
MH  - Real-Time Polymerase Chain Reaction
MH  - Receptors, G-Protein-Coupled/*genetics
MH  - Receptors, Histamine/*genetics
MH  - Receptors, Histamine H1/genetics
MH  - Receptors, Histamine H2/genetics
MH  - Receptors, Histamine H4
MH  - Synovial Membrane/*chemistry
EDAT- 2011/09/02 06:00
MHDA- 2013/02/21 06:00
CRDT- 2011/09/02 06:00
PHST- 2011/01/06 00:00 [received]
PHST- 2011/08/21 00:00 [accepted]
PHST- 2011/09/02 06:00 [entrez]
PHST- 2011/09/02 06:00 [pubmed]
PHST- 2013/02/21 06:00 [medline]
AID - 10.1007/s00296-011-2069-6 [doi]
PST - ppublish
SO  - Rheumatol Int. 2012 Oct;32(10):3309-13. doi: 10.1007/s00296-011-2069-6. Epub 2011 
      Sep 1.