PMID- 21883369
OWN - NLM
STAT- MEDLINE
DCOM- 20120316
LR  - 20111104
IS  - 1600-0560 (Electronic)
IS  - 0303-6987 (Linking)
VI  - 38
IP  - 12
DP  - 2011 Dec
TI  - Histiocytic sarcoma transdifferentiated from follicular lymphoma presenting as a 
      cutaneous tumor.
PG  - 999-1003
LID - 10.1111/j.1600-0560.2011.01769.x [doi]
AB  - Histiocytic sarcoma represents a rare and poorly understood tumor of 
      histiocytic/dendritic cell lineage that can rarely present in the skin. 
      Previously reported cases of histiocytic sarcoma after follicular lymphoma 
      suggested that follicular lymphoma can transdifferentiate into histiocytic 
      sarcoma. We describe another case involving a 40-year old male who developed 
      histiocytic sarcoma in his right thigh 4 years after the diagnosis of grade 1 
      follicular lymphoma in the left neck. The two neoplasms were morphologically and 
      immunophenotypically different but had identical immunoglobulin heavy chain gene 
      and bcl-2 gene rearrangements, as demonstrated by polymerase chain gene reaction 
      analysis, and the presence of t(14;18)(q32;q21) translocation was confirmed via 
      fluorescence in situ hybridization (FISH) analysis. Because of spindle cell 
      morphology and focal S-100 positivity, malignant peripheral nerve sheath tumor 
      and melanoma diagnoses were made initially and extensive workup was required to 
      discover the correct diagnosis. Lineage transdifferentiation can occur in mature 
      lymphoid neoplasms and awareness of this phenomenon and appropriate workup is 
      crucial for correct diagnosis, as different treatment protocols and prognosis may 
      vary.
CI  - Copyright (c) 2011 John Wiley & Sons A/S.
FAU - Zeng, Weifen
AU  - Zeng W
AD  - Department of Pathology, Georgetown University Hospital, Washington, DC, USA.
FAU - Meck, Jeanne
AU  - Meck J
FAU - Cheson, Bruce D
AU  - Cheson BD
FAU - Ozdemirli, Metin
AU  - Ozdemirli M
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20110823
PL  - United States
TA  - J Cutan Pathol
JT  - Journal of cutaneous pathology
JID - 0425124
RN  - 0 (Immunoglobulin Heavy Chains)
SB  - IM
MH  - Adult
MH  - Chromosomes, Human, Pair 14/genetics
MH  - Chromosomes, Human, Pair 18/genetics
MH  - Diagnosis, Differential
MH  - Gene Rearrangement, B-Lymphocyte, Heavy Chain/genetics
MH  - Genes, bcl-2/genetics
MH  - *Histiocytic Sarcoma/genetics/metabolism/pathology
MH  - Humans
MH  - Immunoglobulin Heavy Chains/genetics/metabolism
MH  - In Situ Hybridization, Fluorescence
MH  - *Lymphoma, Follicular/genetics/metabolism/pathology
MH  - Male
MH  - *Skin Neoplasms/genetics/metabolism/pathology
MH  - Translocation, Genetic/genetics
EDAT- 2011/09/03 06:00
MHDA- 2012/03/17 06:00
CRDT- 2011/09/03 06:00
PHST- 2011/09/03 06:00 [entrez]
PHST- 2011/09/03 06:00 [pubmed]
PHST- 2012/03/17 06:00 [medline]
AID - 10.1111/j.1600-0560.2011.01769.x [doi]
PST - ppublish
SO  - J Cutan Pathol. 2011 Dec;38(12):999-1003. doi: 10.1111/j.1600-0560.2011.01769.x. 
      Epub 2011 Aug 23.