PMID- 21883445
OWN - NLM
STAT- MEDLINE
DCOM- 20120525
LR  - 20220408
IS  - 1600-079X (Electronic)
IS  - 0742-3098 (Linking)
VI  - 52
IP  - 2
DP  - 2012 Mar
TI  - Melatonin improves glucose homeostasis in young Zucker diabetic fatty rats.
PG  - 203-10
LID - 10.1111/j.1600-079X.2011.00928.x [doi]
AB  - The aim of this study was to investigate the effects of melatonin on glucose 
      homeostasis in young male Zucker diabetic fatty (ZDF) rats, an experimental model 
      of metabolic syndrome and type 2 diabetes mellitus (T2DM). ZDF rats (n=30) and 
      lean littermates (ZL) (n=30) were used. At 6wk of age, both lean and fatty 
      animals were subdivided into three groups, each composed of ten rats: naive (N), 
      vehicle treated (V), and melatonin treated (M) (10mg/kg/day) for 6wk. Vehicle and 
      melatonin were added to the drinking water. ZDF rats developed DM (fasting 
      hyperglycemia, 460+/-39.8mg/dL; HbA(1) c 8.3+/-0.5%) with both insulin resistance 
      (HOMA-IR 9.28+/-0.9 versus 1.2+/-0.1 in ZL) and decreased beta-cell function (HOMA1-%B) 
      by 75%, compared with ZL rats. Melatonin reduced fasting hyperglycemia by 18.6% 
      (P<0.05) and HbA(1) c by 11% (P<0.05) in ZDF rats. Also, melatonin lowered 
      insulinemia by 15.9% (P<0.05) and HOMA-IR by 31% (P<0.01) and increased HOMA1-%B 
      by 14.4% (P<0.05). In addition, melatonin decreased hyperleptinemia by 34% 
      (P<0.001) and raised hypoadiponectinemia by 40% (P<0.001) in ZDF rats. Moreover, 
      melatonin reduced serum free fatty acid levels by 13.5% (P<0.05). These data 
      demonstrate that oral melatonin administration ameliorates glucose homeostasis in 
      young ZDF rats by improving both insulin action and beta-cell function. These 
      observations have implications on melatonin's possible use as a new pharmacologic 
      therapy for improving glucose homeostasis and of obesity-related T2DM, in young 
      subjects.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Agil, Ahmad
AU  - Agil A
AD  - Deparment of Pharmacology and Neurosciences Institute, School of Medicine, 
      University of Granada, Granada, Spain.
FAU - Rosado, Isaac
AU  - Rosado I
FAU - Ruiz, Rosario
AU  - Ruiz R
FAU - Figueroa, Adriana
AU  - Figueroa A
FAU - Zen, Nourahouda
AU  - Zen N
FAU - Fernandez-Vazquez, Gumersindo
AU  - Fernandez-Vazquez G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110825
PL  - England
TA  - J Pineal Res
JT  - Journal of pineal research
JID - 8504412
RN  - 0 (Antioxidants)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Insulin)
RN  - IY9XDZ35W2 (Glucose)
RN  - JL5DK93RCL (Melatonin)
SB  - IM
MH  - Animals
MH  - Antioxidants/*pharmacology
MH  - Diabetes Mellitus, Type 2/drug therapy/*metabolism
MH  - Disease Models, Animal
MH  - Fatty Acids, Nonesterified/blood
MH  - Glucose/*metabolism
MH  - Homeostasis/*drug effects
MH  - Hyperglycemia/drug therapy/metabolism
MH  - Insulin/blood
MH  - Male
MH  - Melatonin/*pharmacology
MH  - Metabolic Syndrome/drug therapy/metabolism
MH  - Rats
MH  - Rats, Zucker
EDAT- 2011/09/03 06:00
MHDA- 2012/05/26 06:00
CRDT- 2011/09/03 06:00
PHST- 2011/09/03 06:00 [entrez]
PHST- 2011/09/03 06:00 [pubmed]
PHST- 2012/05/26 06:00 [medline]
AID - 10.1111/j.1600-079X.2011.00928.x [doi]
PST - ppublish
SO  - J Pineal Res. 2012 Mar;52(2):203-10. doi: 10.1111/j.1600-079X.2011.00928.x. Epub 
      2011 Aug 25.