PMID- 21884982
OWN - NLM
STAT- MEDLINE
DCOM- 20111222
LR  - 20131121
IS  - 1097-4164 (Electronic)
IS  - 1097-2765 (Linking)
VI  - 43
IP  - 5
DP  - 2011 Sep 2
TI  - Life span extension and H(2)O(2) resistance elicited by caloric restriction 
      require the peroxiredoxin Tsa1 in Saccharomyces cerevisiae.
PG  - 823-33
LID - 10.1016/j.molcel.2011.07.027 [doi]
AB  - Caloric restriction (CR) extends the life span of organisms ranging from yeast to 
      primates. Here, we show that the thiol-dependent peroxiredoxin Tsa1 and its 
      partner sulfiredoxin, Srx1, are required for CR to extend the replicative life 
      span of yeast cells. Tsa1 becomes hyperoxidized/inactive during aging, and CR 
      mitigates such oxidation by elevating the levels of Srx1, which is required to 
      reduce/reactivate hyperoxidized Tsa1. CR, by lowering cAMP-PKA activity, enhances 
      Gcn2-dependent SRX1 translation, resulting in increased resistance to H(2)O(2) 
      and life span extension. Moreover, an extra copy of the SRX1 gene is sufficient 
      to extend the life span of cells grown in high glucose concentrations by 20% in a 
      Tsa1-dependent and Sir2-independent manner. The data demonstrate that Tsa1 is 
      required to ensure yeast longevity and that CR extends yeast life span, in part, 
      by counteracting age-induced hyperoxidation of this peroxiredoxin.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Molin, Mikael
AU  - Molin M
AD  - CMB, University of Gothenburg, Medicinaregatan 9C, S-413 90 Goteborg, Sweden. 
      mikael.molin@cmb.gu.se
FAU - Yang, Junsheng
AU  - Yang J
FAU - Hanzen, Sarah
AU  - Hanzen S
FAU - Toledano, Michel B
AU  - Toledano MB
FAU - Labarre, Jean
AU  - Labarre J
FAU - Nystrom, Thomas
AU  - Nystrom T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Mol Cell
JT  - Molecular cell
JID - 9802571
RN  - 0 (Saccharomyces cerevisiae Proteins)
RN  - BBX060AN9V (Hydrogen Peroxide)
RN  - EC 1.11.1.- (Peroxidases)
RN  - EC 1.11.1.- (Tsa1 protein, S cerevisiae)
RN  - EC 1.8.- (Oxidoreductases Acting on Sulfur Group Donors)
RN  - EC 1.8.- (SRX1 protein, S cerevisiae)
SB  - IM
CIN - Mol Cell. 2011 Sep 2;43(5):699-701. PMID: 21884972
MH  - Caloric Restriction
MH  - Hydrogen Peroxide/*metabolism
MH  - Oxidoreductases Acting on Sulfur Group Donors/genetics/metabolism
MH  - Peroxidases/genetics/*metabolism
MH  - Saccharomyces cerevisiae/metabolism/*physiology
MH  - Saccharomyces cerevisiae Proteins/genetics/*metabolism
EDAT- 2011/09/03 06:00
MHDA- 2011/12/23 06:00
CRDT- 2011/09/03 06:00
PHST- 2010/09/20 00:00 [received]
PHST- 2011/01/03 00:00 [revised]
PHST- 2011/07/09 00:00 [accepted]
PHST- 2011/09/03 06:00 [entrez]
PHST- 2011/09/03 06:00 [pubmed]
PHST- 2011/12/23 06:00 [medline]
AID - S1097-2765(11)00626-5 [pii]
AID - 10.1016/j.molcel.2011.07.027 [doi]
PST - ppublish
SO  - Mol Cell. 2011 Sep 2;43(5):823-33. doi: 10.1016/j.molcel.2011.07.027.