PMID- 21885396
OWN - NLM
STAT- MEDLINE
DCOM- 20120829
LR  - 20220311
IS  - 1399-3003 (Electronic)
IS  - 0903-1936 (Linking)
VI  - 39
IP  - 5
DP  - 2012 May
TI  - Overweight is not a comorbidity factor during childhood asthma: the GrowthOb 
      study.
PG  - 1120-6
LID - 10.1183/09031936.00103311 [doi]
AB  - While being overweight is a risk factor for subsequent asthma in children, the 
      importance of body mass index (BMI) as a comorbidity factor remains debated. The 
      aim of this study was to assess the relationships between being overweight and 
      the characteristics of childhood asthma. The BMI, BMI z-scores and International 
      Obesity Task Force (IOTF) grades were evaluated in asthmatic children according 
      to atopic status, symptoms during the past 3 months, exercise breathlessness, 
      treatment and lung function in 6-15-yr-old children with confirmed asthma. 491 
      asthmatic children (mean +/- SD age 10.8 +/- 2.6 yrs; 179 females) were prospectively 
      enrolled. There were 78 (15.5%) overweight (IOTF grade 1) and eight (1.6%) obese 
      (grade 2) children. The children's BMI z-scores did not differ according to 
      atopy, exacerbation, symptom-free days or treatment. The BMI z-score correlated 
      positively with forced vital capacity and forced expiratory volume in 1 s in 
      females, which could be related to earlier puberty in overweight females (growth 
      spurt with increased volumes). Compared with normal weight children, overweight 
      and obese children had reduced lung volume ratios (functional residual 
      capacity/total lung capacity (TLC) and residual volume/TLC), no evidence of 
      airflow limitation and similar symptoms. In conclusion, the observed functional 
      relationships with BMI are not specific to asthma and being overweight is not 
      associated with significant clinical impacts on asthma during childhood.
FAU - Mahut, Bruno
AU  - Mahut B
AD  - AP-HP, Hopital Europeen Georges-Pompidou, Service de Physiologie, Clinique de la 
      Dyspnee, Paris, France.
FAU - Beydon, Nicole
AU  - Beydon N
FAU - Delclaux, Christophe
AU  - Delclaux C
LA  - eng
PT  - Journal Article
DEP - 20110901
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - 0 (Anti-Asthmatic Agents)
SB  - IM
MH  - Adolescent
MH  - Anti-Asthmatic Agents/therapeutic use
MH  - Asthma/drug therapy/*epidemiology
MH  - Body Mass Index
MH  - Child
MH  - Comorbidity
MH  - Female
MH  - Humans
MH  - Lung/physiopathology
MH  - Male
MH  - Overweight/*epidemiology
MH  - Respiratory Function Tests
MH  - Severity of Illness Index
EDAT- 2011/09/03 06:00
MHDA- 2012/08/30 06:00
CRDT- 2011/09/03 06:00
PHST- 2011/09/03 06:00 [entrez]
PHST- 2011/09/03 06:00 [pubmed]
PHST- 2012/08/30 06:00 [medline]
AID - 09031936.00103311 [pii]
AID - 10.1183/09031936.00103311 [doi]
PST - ppublish
SO  - Eur Respir J. 2012 May;39(5):1120-6. doi: 10.1183/09031936.00103311. Epub 2011 
      Sep 1.