PMID- 21886568
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1875-6190 (Electronic)
IS  - 1570-159X (Print)
IS  - 1570-159X (Linking)
VI  - 9
IP  - 1
DP  - 2011 Mar
TI  - The Nature of 3, 4-Methylenedioxymethamphetamine (MDMA)-Induced Serotonergic 
      Dysfunction: Evidence for and Against the Neurodegeneration Hypothesis.
PG  - 84-90
LID - 10.2174/157015911795017146 [doi]
AB  - High doses of the recreational drug 3,4-methylenedioxymethamphetamine (MDMA, 
      "Ecstasy") have been well-documented to reduce the expression of serotonergic 
      markers in several forebrain regions of rats and nonhuman primates. Neuroimaging 
      studies further suggest that at least one of these markers, the plasma membrane 
      serotonin transporter (SERT), may also be reduced in heavy Ecstasy users. Such 
      effects, particularly when observed in experimental animal models, have generally 
      been interpreted as reflecting a loss of serotonergic fibers and terminals 
      following MDMA exposure. This view has been challenged, however, based on the 
      finding that MDMA usually does not elicit glial cell reactions known to occur in 
      response to central nervous system (CNS) damage. The aim of this review is to 
      address both sides of the MDMA-neurotoxicity controversy, including recent 
      findings from our laboratory regarding the potential of MDMA to induce 
      serotonergic damage in a rat binge model. Our data add to the growing literature 
      implicating neuroregulatory mechanisms underlying MDMA-induced serotonergic 
      dysfunction and questioning the need to invoke a degenerative response to explain 
      such dysfunction.
FAU - Biezonski, Dominik K
AU  - Biezonski DK
AD  - Neuroscience and Behavior Program, University of Massachusetts, Amherst MA 01003, 
      USA.
FAU - Meyer, Jerrold S
AU  - Meyer JS
LA  - eng
PT  - Journal Article
PL  - United Arab Emirates
TA  - Curr Neuropharmacol
JT  - Current neuropharmacology
JID - 101157239
PMC - PMC3137208
OTO - NOTNLM
OT  - MDMA
OT  - biochemical downregulation.
OT  - gene expression
OT  - neurodegeneration
OT  - neurotoxicity
OT  - serotonin
OT  - serotonin transporter
OT  - vesicular monoamine transporter 2
EDAT- 2011/09/03 06:00
MHDA- 2011/09/03 06:01
PMCR- 2011/09/01
CRDT- 2011/09/03 06:00
PHST- 2009/10/01 00:00 [received]
PHST- 2010/04/17 00:00 [revised]
PHST- 2010/05/26 00:00 [accepted]
PHST- 2011/09/03 06:00 [entrez]
PHST- 2011/09/03 06:00 [pubmed]
PHST- 2011/09/03 06:01 [medline]
PHST- 2011/09/01 00:00 [pmc-release]
AID - CN-9-84 [pii]
AID - 10.2174/157015911795017146 [doi]
PST - ppublish
SO  - Curr Neuropharmacol. 2011 Mar;9(1):84-90. doi: 10.2174/157015911795017146.