PMID- 21886569
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1875-6190 (Electronic)
IS  - 1570-159X (Print)
IS  - 1570-159X (Linking)
VI  - 9
IP  - 1
DP  - 2011 Mar
TI  - Effects of MDMA on Extracellular Dopamine and Serotonin Levels in Mice Lacking 
      Dopamine and/or Serotonin Transporters.
PG  - 91-5
LID - 10.2174/157015911795017254 [doi]
AB  - 3,4-Methylendioxymethamphetamine (MDMA) has both stimulatory and hallucinogenic 
      properties which make its psychoactive effects unique and different from those of 
      typical psychostimulant and hallucinogenic agents. The present study investigated 
      the effects of MDMA on extracellular dopamine (DA(ex)) and serotonin (5-HT(ex)) 
      levels in the striatum and prefrontal cortex (PFC) using in vivo microdialysis 
      techniques in mice lacking DA transporters (DAT) and/or 5-HT transporters (SERT). 
      subcutaneous injection of MDMA (3, 10 mg/kg) significantly increased striatal 
      DA(ex) in wild-type mice, SERT knockout mice, and DAT knockout mice, but not in 
      DAT/SERT double-knockout mice. The MDMA-induced increase in striatal DA(ex) in 
      SERT knockout mice was significantly less than in wildtype mice. In the PFC, MDMA 
      dose-dependently increased DA(ex) levels in wildtype, DAT knockout, SERT knockout 
      and DAT/SERT double-knockout mice to a similar extent. In contrast, MDMA markedly 
      increased 5-HT(ex) in wildtype and DAT knockout mice and slightly increased 
      5-HT(ex) in SERT-KO and DAT/SERT double-knockout mice. The results confirm that 
      MDMA acts at both DAT and SERT and increases DA(ex) and 5-HT(ex).
FAU - Hagino, Y
AU  - Hagino Y
AD  - Division of Psychobiology, Tokyo Institute of Psychiatry, Tokyo 156-8585, Japan.
FAU - Takamatsu, Y
AU  - Takamatsu Y
FAU - Yamamoto, H
AU  - Yamamoto H
FAU - Iwamura, T
AU  - Iwamura T
FAU - Murphy, D L
AU  - Murphy DL
FAU - Uhl, G R
AU  - Uhl GR
FAU - Sora, I
AU  - Sora I
FAU - Ikeda, K
AU  - Ikeda K
LA  - eng
PT  - Journal Article
PL  - United Arab Emirates
TA  - Curr Neuropharmacol
JT  - Current neuropharmacology
JID - 101157239
PMC - PMC3137209
OTO - NOTNLM
OT  - MDMA
OT  - dopamine transporter
OT  - knockout
OT  - microdialysis.
OT  - serotonin transporter
EDAT- 2011/09/03 06:00
MHDA- 2011/09/03 06:01
PMCR- 2011/09/01
CRDT- 2011/09/03 06:00
PHST- 2009/10/01 00:00 [received]
PHST- 2010/04/17 00:00 [revised]
PHST- 2010/05/26 00:00 [accepted]
PHST- 2011/09/03 06:00 [entrez]
PHST- 2011/09/03 06:00 [pubmed]
PHST- 2011/09/03 06:01 [medline]
PHST- 2011/09/01 00:00 [pmc-release]
AID - CN-9-91 [pii]
AID - 10.2174/157015911795017254 [doi]
PST - ppublish
SO  - Curr Neuropharmacol. 2011 Mar;9(1):91-5. doi: 10.2174/157015911795017254.