PMID- 21887154
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 1746-0794 (Print)
IS  - 1746-0808 (Electronic)
IS  - 1746-0794 (Linking)
VI  - 6
IP  - 8
DP  - 2011 Aug
TI  - Central role of dendritic cells in shaping the adaptive immune response during 
      respiratory syncytial virus infection.
PG  - 963-973
AB  - Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract 
      disease in young children. Premature infants, immunocompromised individuals and 
      the elderly exhibit the highest risk for the development of severe RSV-induced 
      disease. Murine studies demonstrate that CD8 T cells mediate RSV clearance from 
      the lungs. Murine studies also indicate that the host immune response contributes 
      to RSV-induced morbidity as T-cell depletion prevents the development of disease 
      despite sustained viral replication. Dendritic cells (DCs) play a central role in 
      the induction of the RSV-specific adaptive immune response. Following RSV 
      infection, lung-resident DCs acquire viral antigens, migrate to the lung-draining 
      lymph nodes and initiate the T-cell response. This article focuses on data 
      generated from both in vitro DC infection studies and RSV mouse models that 
      together have advanced our understanding of how RSV infection modulates DC 
      function and the subsequent impact on the adaptive immune response.
FAU - McDermott, Daniel S
AU  - McDermott DS
AD  - Interdisciplinary Graduate Program in Immunology, 51 Newton Road, 3-532 Bowen 
      Science Building, University of Iowa, Iowa City, IA 52242, USA.
FAU - Weiss, Kayla A
AU  - Weiss KA
FAU - Knudson, Cory J
AU  - Knudson CJ
FAU - Varga, Steven M
AU  - Varga SM
LA  - eng
GR  - R01 AI063520/AI/NIAID NIH HHS/United States
GR  - R01 AI063520-05/AI/NIAID NIH HHS/United States
PT  - Journal Article
PL  - England
TA  - Future Virol
JT  - Future virology
JID - 101278124
PMC - PMC3163480
MID - NIHMS316976
EDAT- 2011/09/03 06:00
MHDA- 2011/09/03 06:01
PMCR- 2012/06/01
CRDT- 2011/09/03 06:00
PHST- 2011/09/03 06:00 [entrez]
PHST- 2011/09/03 06:00 [pubmed]
PHST- 2011/09/03 06:01 [medline]
PHST- 2012/06/01 00:00 [pmc-release]
AID - 10.2217/fvl.11.62 [doi]
PST - ppublish
SO  - Future Virol. 2011 Aug;6(8):963-973. doi: 10.2217/fvl.11.62.