PMID- 21889214
OWN - NLM
STAT- MEDLINE
DCOM- 20111219
LR  - 20111031
IS  - 1872-8421 (Electronic)
IS  - 0165-5728 (Linking)
VI  - 239
IP  - 1-2
DP  - 2011 Oct 28
TI  - Targeting Toll-like receptors: emerging therapeutics for multiple sclerosis 
      management.
PG  - 1-12
LID - 10.1016/j.jneuroim.2011.08.010 [doi]
AB  - Toll-like receptors (TLR) are important innate immune proteins for the 
      identification and clearance of invading pathogen. TLR signal through adaptor 
      proteins, most commonly myeloid differentiation primary response gene 88 (MyD88). 
      Inappropriate response of specific TLR has been implicated in certain autoimmune 
      diseases, such as multiple sclerosis (MS). Activation of TLR2, TLR4, TLR7 and 
      TLR9 plays a role in experimental allergic encephalomyelitis (EAE), a murine 
      model of MS, while TLR3 activation protects from disease. Therefore, 
      TLR-modulation could be an important adjuvant to current treatments. Here, we 
      focus on TLR involved in EAE and MS pathogenesis highlighting specific components 
      targeting TLR that might offer further therapeutic possibilities.
CI  - Copyright A(c) 2011 Elsevier B.V. All rights reserved.
FAU - Gambuzza, M
AU  - Gambuzza M
AD  - Department of Experimental Pathology and Microbiology, University of Messina, 
      Messina, Italy. gambuzza2002@yahoo.it
FAU - Licata, N
AU  - Licata N
FAU - Palella, E
AU  - Palella E
FAU - Celi, D
AU  - Celi D
FAU - Foti Cuzzola, V
AU  - Foti Cuzzola V
FAU - Italiano, D
AU  - Italiano D
FAU - Marino, S
AU  - Marino S
FAU - Bramanti, P
AU  - Bramanti P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110901
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Toll-Like Receptors)
SB  - IM
MH  - Animals
MH  - Complementary Therapies/methods/trends
MH  - Disease Models, Animal
MH  - Humans
MH  - Molecular Targeted Therapy/*methods/*trends
MH  - Multiple Sclerosis/*drug therapy/*immunology/pathology
MH  - Signal Transduction/drug effects/*immunology
MH  - Toll-Like Receptors/agonists/*metabolism/physiology
EDAT- 2011/09/06 06:00
MHDA- 2011/12/20 06:00
CRDT- 2011/09/06 06:00
PHST- 2011/03/15 00:00 [received]
PHST- 2011/06/09 00:00 [revised]
PHST- 2011/08/10 00:00 [accepted]
PHST- 2011/09/06 06:00 [entrez]
PHST- 2011/09/06 06:00 [pubmed]
PHST- 2011/12/20 06:00 [medline]
AID - S0165-5728(11)00227-X [pii]
AID - 10.1016/j.jneuroim.2011.08.010 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2011 Oct 28;239(1-2):1-12. doi: 10.1016/j.jneuroim.2011.08.010. 
      Epub 2011 Sep 1.