PMID- 21889332
OWN - NLM
STAT- MEDLINE
DCOM- 20120918
LR  - 20220409
IS  - 1879-0852 (Electronic)
IS  - 0959-8049 (Linking)
VI  - 48
IP  - 9
DP  - 2012 Jun
TI  - Type 2 diabetes mellitus and colorectal cancer: meta-analysis on sex-specific 
      differences.
PG  - 1269-82
LID - 10.1016/j.ejca.2011.07.010 [doi]
AB  - Although there is consent concerning a higher risk for colorectal cancer (CRC) 
      amongst patients with type 2 diabetes mellitus (T2DM), there remains uncertainty 
      regarding potential sex differences in the strength of this association. We 
      reviewed and summarised epidemiological studies assessing the sex-specific 
      association of T2DM with the risk for CRC. All relevant studies published until 
      14th February 2011 were identified by a systematic search of MEDLINE, EMBASE, 
      BIOSIS Previews and ISI Web of Knowledge databases and cross-referencing. We 
      included observational studies that reported relative risk (RR) or odds ratio 
      (OR) estimates with 95% confidence intervals (CIs) for the association between 
      T2DM and CRC. Two authors independently extracted data and assessed study quality 
      of each study in a standardised manner. Study-specific estimates were pooled for 
      both sexes separately using random-effects models. A total of 29 eligible studies 
      were used for meta-analysis. Overall estimates of relative risk (RR) were very 
      similar amongst men (RR=1.29; 95%-confidence interval (CI): 1.19-1.140) and women 
      (RR=1.34; 95%-CI: 1.22-1.47). In both men and women, risk estimates from 
      case-control studies were slightly higher than those from cohort studies. 
      Overall, T2DM is associated with a moderate increase in CRC risk in both men and 
      women.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Kramer, Heike U
AU  - Kramer HU
AD  - Division of Clinical Epidemiology and Aging Research, German Cancer Research 
      Center, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.
FAU - Schottker, Ben
AU  - Schottker B
FAU - Raum, Elke
AU  - Raum E
FAU - Brenner, Hermann
AU  - Brenner H
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20110831
PL  - England
TA  - Eur J Cancer
JT  - European journal of cancer (Oxford, England : 1990)
JID - 9005373
SB  - IM
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Colorectal Neoplasms/*etiology
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Humans
MH  - Sex Factors
EDAT- 2011/09/06 06:00
MHDA- 2012/09/19 06:00
CRDT- 2011/09/06 06:00
PHST- 2011/05/18 00:00 [received]
PHST- 2011/07/13 00:00 [revised]
PHST- 2011/07/15 00:00 [accepted]
PHST- 2011/09/06 06:00 [entrez]
PHST- 2011/09/06 06:00 [pubmed]
PHST- 2012/09/19 06:00 [medline]
AID - S0959-8049(11)00506-5 [pii]
AID - 10.1016/j.ejca.2011.07.010 [doi]
PST - ppublish
SO  - Eur J Cancer. 2012 Jun;48(9):1269-82. doi: 10.1016/j.ejca.2011.07.010. Epub 2011 
      Aug 31.