PMID- 21890535
OWN - NLM
STAT- MEDLINE
DCOM- 20130205
LR  - 20151119
IS  - 2047-4881 (Electronic)
IS  - 2047-4873 (Linking)
VI  - 19
IP  - 5
DP  - 2012 Oct
TI  - Plasma calprotectin levels reflect disease severity in patients with chronic 
      heart failure.
PG  - 999-1004
LID - 10.1177/1741826711421078 [doi]
AB  - BACKGROUND: Low-grade inflammation has been associated with cardiovascular 
      disease (CVD) and chronic heart failure (CHF). The aim of the present study was 
      to investigate the potential usefulness of the inflammatory protein calprotectin 
      as a biomarker in CHF. METHODS: Plasma calprotectin was measured in 193 CHF 
      patients with left ventricular function <45% and in 100 healthy controls at 
      baseline. Patients with CHF were followed for a median period of 2.6 years 
      according to mortality. RESULTS: The levels of plasma calprotectin were 
      significantly increased in the CHF patients compared to the control group (P < 
      0.01), primarily due to elevated levels in the patients with New York Heart 
      Association (NYHA) class III and IV. Furthermore, plasma calprotectin was a 
      superior biomarker of high NYHA classes than other parameters reflecting CHF 
      severity, OR 2.2 (1.1-4.3) (P = 0.019). After the follow-up period, 46 patients 
      had died. Plasma calprotectin levels did not predict mortality in CHF patients. 
      CONCLUSIONS: Plasma calprotectin is increased in CHF patients, indicating that 
      inflammatory activity is upregulated in CHF and may be associated with the 
      severity of CHF.
FAU - Jensen, Louise J N
AU  - Jensen LJ
AD  - The Medical Research Laboratories, Institute of Clinical Medicine, Aarhus 
      University and Department of Endocrinology and Internal Medicine, Aarhus 
      University Hospital, Aarhus, Denmark. ljnoergaard@hotmail.com
FAU - Kistorp, Caroline
AU  - Kistorp C
FAU - Bjerre, Mette
AU  - Bjerre M
FAU - Raymond, Ilan
AU  - Raymond I
FAU - Flyvbjerg, Allan
AU  - Flyvbjerg A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110902
PL  - England
TA  - Eur J Prev Cardiol
JT  - European journal of preventive cardiology
JID - 101564430
RN  - 0 (Biomarkers)
RN  - 0 (Leukocyte L1 Antigen Complex)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Denmark/epidemiology
MH  - Echocardiography
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/*blood/diagnosis/mortality
MH  - Humans
MH  - Leukocyte L1 Antigen Complex/*blood
MH  - Male
MH  - Prognosis
MH  - Severity of Illness Index
MH  - Stroke Volume
MH  - Survival Rate/trends
MH  - Ventricular Function, Left/*physiology
EDAT- 2011/09/06 06:00
MHDA- 2013/02/06 06:00
CRDT- 2011/09/06 06:00
PHST- 2011/09/06 06:00 [entrez]
PHST- 2011/09/06 06:00 [pubmed]
PHST- 2013/02/06 06:00 [medline]
AID - 1741826711421078 [pii]
AID - 10.1177/1741826711421078 [doi]
PST - ppublish
SO  - Eur J Prev Cardiol. 2012 Oct;19(5):999-1004. doi: 10.1177/1741826711421078. Epub 
      2011 Sep 2.