PMID- 21893216
OWN - NLM
STAT- MEDLINE
DCOM- 20120413
LR  - 20220318
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 11
IP  - 12
DP  - 2011 Dec
TI  - Lactobacillus plantarum strain YU from fermented foods activates Th1 and 
      protective immune responses.
PG  - 2017-24
LID - 10.1016/j.intimp.2011.08.013 [doi]
AB  - Lactic acid bacteria (LAB) are known to have effects on immune function. From 203 
      strains of LAB isolated from fermented foods, we selected a beneficial strain, 
      Lactobacillus plantarum strain YU (LpYU), which has high interleukin 
      (IL)-12-inducing activity in mouse peritoneal macrophages. This activity of LpYU 
      was partially mediated by Toll-like receptor (TLR) 2, but not TLR4 or TLR9. Oral 
      administration of LpYU to ovalbumin (OVA)-immunized mice caused suppression of 
      serum OVA-specific immunoglobulin E (IgE) levels, enhancing interferon (IFN)-gamma 
      production from spleen cells in response to OVA. Furthermore, LpYU enhanced 
      natural killer cell activity in spleen cells and the production of IgA from 
      Peyer's patch cells. Because activation of Th1 immune responses and IgA 
      production induce antiviral effects, we evaluated the inhibitory effects of LpYU 
      against the influenza A virus (A/NWS/33, H1N1) (IFV). Oral administration of LpYU 
      suppressed viral proliferation in the lungs and in bronchoalveolar lavage fluids 
      (BALFs). Both levels of IFV-specific secretory IgA in BALF and feces and titers 
      of IFV-specific neutralizing antibody in BALFs and sera were increased. These 
      results indicate that LpYU has a protective effect against IFV replication. We 
      conclude that this strain has a beneficial effect in activating Th1 immune 
      responses and preventing viral infection.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Kawashima, Tadaomi
AU  - Kawashima T
AD  - Research and Development Division, Kikkoman Corporation, Chiba, Japan. 
      takawashima@mail.kikkoman.co.jp
FAU - Hayashi, Kyoko
AU  - Hayashi K
FAU - Kosaka, Akemi
AU  - Kosaka A
FAU - Kawashima, Megumi
AU  - Kawashima M
FAU - Igarashi, Toshinori
AU  - Igarashi T
FAU - Tsutsui, Hiroko
AU  - Tsutsui H
FAU - Tsuji, Noriko M
AU  - Tsuji NM
FAU - Nishimura, Ikuko
AU  - Nishimura I
FAU - Hayashi, Toshimitsu
AU  - Hayashi T
FAU - Obata, Akio
AU  - Obata A
LA  - eng
PT  - Journal Article
DEP - 20110903
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (Antibodies, Neutralizing)
RN  - 0 (Immunoglobulin A)
RN  - 0 (Tlr2 protein, mouse)
RN  - 0 (Toll-Like Receptor 2)
RN  - 187348-17-0 (Interleukin-12)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Antibodies, Neutralizing/blood
MH  - Bronchoalveolar Lavage Fluid/immunology/virology
MH  - Cell Proliferation
MH  - Feces/microbiology
MH  - Immunoglobulin A/biosynthesis/immunology
MH  - Immunoglobulin E/blood
MH  - Influenza A virus/*immunology
MH  - Interferon-gamma/biosynthesis/immunology
MH  - Interleukin-12/biosynthesis/immunology
MH  - Killer Cells, Natural/immunology/metabolism/microbiology
MH  - Lactobacillus plantarum/*immunology
MH  - Lung/immunology/virology
MH  - Macrophages, Peritoneal/immunology/metabolism/microbiology
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Orthomyxoviridae Infections/*immunology/microbiology
MH  - Peyer's Patches/immunology/metabolism/microbiology
MH  - Probiotics/*administration & dosage
MH  - Spleen/immunology/metabolism/microbiology
MH  - Th1 Cells/*immunology/microbiology
MH  - Toll-Like Receptor 2/immunology
MH  - Treatment Outcome
EDAT- 2011/09/07 06:00
MHDA- 2012/04/14 06:00
CRDT- 2011/09/07 06:00
PHST- 2011/04/01 00:00 [received]
PHST- 2011/08/18 00:00 [revised]
PHST- 2011/08/21 00:00 [accepted]
PHST- 2011/09/07 06:00 [entrez]
PHST- 2011/09/07 06:00 [pubmed]
PHST- 2012/04/14 06:00 [medline]
AID - S1567-5769(11)00333-X [pii]
AID - 10.1016/j.intimp.2011.08.013 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2011 Dec;11(12):2017-24. doi: 10.1016/j.intimp.2011.08.013. 
      Epub 2011 Sep 3.