PMID- 21894771
OWN - NLM
STAT- MEDLINE
DCOM- 20111005
LR  - 20130823
IS  - 1343-3490 (Print)
IS  - 1343-3490 (Linking)
VI  - 49
IP  - 8
DP  - 2011 Aug
TI  - [Multidisciplinary assessment of effects, safety and procedure of whole lung 
      lavage for 8 patients with autoimmune pulmonary alveolar proteinosis].
PG  - 569-76
AB  - We treated 8 cases of autoimmune pulmonary alveolar proteinosis (APAP) with whole 
      lung lavage (WLL) in our hospital and evaluated the disease severity of APAP 
      before and after WLL, adverse events (AEs) and recurrence-free survival in those 
      cases who improved. In all cases, unilateral WLL was performed in both lungs. The 
      median of total lavage volume in unilateral WLL was 17.9 L, and the median 
      procedure time of unilateral WLL was 105 min. Fever was the most frequently 
      observed AE (87.5% of all procedures). Pulmonary function tests (percentage of 
      predicted value of VC, FEV1 and diffusing capacity of carbon monoxide), serum 
      markers (KL-6, surfactant apoprotein (SP)-D, SP-A and carcinoembryonic antigens), 
      arterial blood gas analyses (PaO2, AaDO2) and disease severity score all 
      significantly improved after WLL. The serum levels of anti-granulocyte-macrophage 
      colony-stimulating factor (GM-CSF) antibody temporarily decreased after 
      unilateral WLL, but returned to previous levels (before WLL) in 7 cases. The 
      radiological findings improved in 6 cases. In the 7 improved cases in whom AaDO2 
      decreased more than 10 Torr, the median recurrence-free survival of APAP after 
      WLL was 17.5 months. We concluded that WLL is an effective and safe method for 
      the treatment of APAP, and all parameters except for anti GM-CSF antibody are 
      useful to evaluate the effect of WLL.
FAU - Sugimoto, Chikatoshi
AU  - Sugimoto C
AD  - Department of Internal Medicine, National Hospital Organization Kinki-Chuo Chest 
      Medical Center.
FAU - Arai, Toru
AU  - Arai T
FAU - Nishiyama, Akihide
AU  - Nishiyama A
FAU - Inoue, Yasushi
AU  - Inoue Y
FAU - Kagawa, Tomoko
AU  - Kagawa T
FAU - Akira, Masanori
AU  - Akira M
FAU - Matsumuro, Akiko
AU  - Matsumuro A
FAU - Hirose, Masaki
AU  - Hirose M
FAU - Kitaichi, Masanori
AU  - Kitaichi M
FAU - Hayashi, Seiji
AU  - Hayashi S
FAU - Inoue, Yoshikazu
AU  - Inoue Y
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Nihon Kokyuki Gakkai Zasshi
JT  - Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society
JID - 9808802
SB  - IM
MH  - Adult
MH  - Aged
MH  - Autoimmune Diseases/mortality/*therapy
MH  - Blood Gas Analysis
MH  - Female
MH  - Humans
MH  - *Lung
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Alveolar Proteinosis/mortality/*therapy
MH  - Therapeutic Irrigation/*methods/standards
MH  - Treatment Outcome
EDAT- 2011/09/08 06:00
MHDA- 2011/10/06 06:00
CRDT- 2011/09/08 06:00
PHST- 2011/09/08 06:00 [entrez]
PHST- 2011/09/08 06:00 [pubmed]
PHST- 2011/10/06 06:00 [medline]
PST - ppublish
SO  - Nihon Kokyuki Gakkai Zasshi. 2011 Aug;49(8):569-76.