PMID- 21894799
OWN - NLM
STAT- MEDLINE
DCOM- 20111006
LR  - 20191112
IS  - 0001-5385 (Print)
IS  - 0001-5385 (Linking)
VI  - 66
IP  - 4
DP  - 2011 Aug
TI  - Clinical outcomes of brief versus prolonged unfractionated heparin infusion after 
      primary percutaneous coronary intervention for ST-segment elevation myocardial 
      infarction in the drug-eluting stent era: real-world, single-centre experience.
PG  - 439-45
AB  - OBJECTIVE: Optimal dose and duration of intravenous unfractionated heparin (UFH) 
      infusion after primary percutaneous coronary intervention (PCI) for ST-segment 
      elevation myocardial infarction (STEMI) are unknown when glycoprotein IIb/IIIa 
      inhibitors (GPIs) are not used. We evaluated the clinical outcomes in patients 
      who received brief versus prolonged UFH infusion following primary PCI for STEMI 
      in the era of drug-eluting stents (DES). METHODS: We studied 273 (216 men, 63 +/- 
      12 years) consecutive patients who underwent primary PCI with DES implantation 
      for STEMI between December 2003 and May 2009. All patients received currently 
      recommended loading and maintenance doses of aspirin and clopidogrel. In-hospital 
      and cumulative 30-day rates of major adverse cardiovascular events (MACEs) and 
      major bleeding were compared between patients receiving brief (< 48 (26 +/- 15) 
      hours, group 1) and those receiving prolonged (> or = 48 (83 +/- 38) hours, group 
      2) infusion of intravenous UFH following index procedure. RESULTS: The 
      demographic and baseline angiographic characteristics were similar between the 
      two groups. In-hospital and cumulative 30-day MACEs rates and major bleeding 
      events rates were not statistically different between groups. CONCLUSION: In this 
      single-centre experience, in patients with STEMI who underwent primary PCI in the 
      era of DES, a routine post-procedure course of UFH infusion for more than 48 
      hours was not associated with any significant benefits. Further study is 
      warranted to determine the optimal duration and dose of administration of UFH 
      infusion following primary PCI.
FAU - Yoo, Sang-Yong
AU  - Yoo SY
AD  - Division of Cardiology, Gangneung Asan Hospital, South Korea.
FAU - Shin, Dae-Hee
AU  - Shin DH
FAU - Lee, Jong-Young
AU  - Lee JY
FAU - Cheong, Sangsig
AU  - Cheong S
FAU - Jang, Jin-Kun
AU  - Jang JK
FAU - Lee, Changkun
AU  - Lee C
LA  - eng
PT  - Journal Article
PL  - England
TA  - Acta Cardiol
JT  - Acta cardiologica
JID - 0370570
RN  - 0 (Anticoagulants)
RN  - 0 (Thiazoles)
RN  - 4165-34-8 (2-n-propylthiazolidine-4-carboxylic acid)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Aged
MH  - Anticoagulants/*administration & dosage
MH  - Coronary Angiography
MH  - Drug-Eluting Stents
MH  - Female
MH  - Heparin/*administration & dosage
MH  - Hospital Mortality
MH  - Humans
MH  - Infusions, Intravenous
MH  - Intra-Aortic Balloon Pumping
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*therapy
MH  - Retrospective Studies
MH  - *Thiazoles
EDAT- 2011/09/08 06:00
MHDA- 2011/10/07 06:00
CRDT- 2011/09/08 06:00
PHST- 2011/09/08 06:00 [entrez]
PHST- 2011/09/08 06:00 [pubmed]
PHST- 2011/10/07 06:00 [medline]
AID - 10.1080/ac.66.4.2126591 [doi]
PST - ppublish
SO  - Acta Cardiol. 2011 Aug;66(4):439-45. doi: 10.1080/ac.66.4.2126591.