PMID- 21895482
OWN - NLM
STAT- MEDLINE
DCOM- 20120116
LR  - 20211020
IS  - 1557-9042 (Electronic)
IS  - 0897-7151 (Print)
IS  - 0897-7151 (Linking)
VI  - 28
IP  - 9
DP  - 2011 Sep
TI  - Quantitative relationship between axonal injury and mechanical response in a 
      rodent head impact acceleration model.
PG  - 1767-82
LID - 10.1089/neu.2010.1687 [doi]
AB  - A modified Marmarou impact acceleration model was developed to study the 
      mechanical responses induced by this model and their correlation to traumatic 
      axonal injury (TAI). Traumatic brain injury (TBI) was induced in 31 anesthetized 
      male Sprague-Dawley rats (392+/-13 g) by a custom-made 450-g impactor from heights 
      of 1.25 m or 2.25 m. An accelerometer and angular rate sensor measured the linear 
      and angular responses of the head, while the impact event was captured by a 
      high-speed video camera. TAI distribution along the rostro-caudal direction, as 
      well as across the left and right hemispheres, was determined using beta-amyloid 
      precursor protein (beta-APP) immunocytochemistry, and detailed TAI injury maps were 
      constructed for the entire corpus callosum. Peak linear acceleration 1.25 m and 
      2.25 m impacts were 666+/-165 g and 907+/-501 g, respectively. Peak angular 
      velocities were 95+/-24 rad/sec and 124+/-48 rad/sec, respectively. Compared to the 
      2.25-m group, the observed TAI counts in the 1.25-m impact group were 
      significantly lower. Average linear acceleration, peak angular velocity, average 
      angular acceleration, and surface righting time were also significantly different 
      between the two groups. A positive correlation was observed between normalized 
      total TAI counts and average linear acceleration (R(2)=0.612, p<0.05), and time 
      to surface right (R(2)=0.545, p<0.05). Our study suggested that a 2.25-m drop in 
      the Marmarou model may not always result in a severe injury, and TAI level is 
      related to the linear and angular acceleration response of the rat head during 
      impact, not necessarily the drop height.
FAU - Li, Yan
AU  - Li Y
AD  - Department of Biomedical Engineering, Wayne State University, Detroit, Michigan 
      48201, USA.
FAU - Zhang, Liying
AU  - Zhang L
FAU - Kallakuri, Srinivasu
AU  - Kallakuri S
FAU - Zhou, Runzhou
AU  - Zhou R
FAU - Cavanaugh, John M
AU  - Cavanaugh JM
LA  - eng
GR  - R01 EB006508/EB/NIBIB NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110906
PL  - United States
TA  - J Neurotrauma
JT  - Journal of neurotrauma
JID - 8811626
SB  - IM
MH  - Acceleration
MH  - Animals
MH  - Axons/metabolism/*pathology
MH  - Brain/metabolism/*pathology
MH  - Diffuse Axonal Injury/metabolism/*pathology
MH  - Head
MH  - Male
MH  - Models, Animal
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Rotation
PMC - PMC3172873
EDAT- 2011/09/08 06:00
MHDA- 2012/01/17 06:00
PMCR- 2012/09/01
CRDT- 2011/09/08 06:00
PHST- 2011/09/08 06:00 [entrez]
PHST- 2011/09/08 06:00 [pubmed]
PHST- 2012/01/17 06:00 [medline]
PHST- 2012/09/01 00:00 [pmc-release]
AID - 10.1089/neu.2010.1687 [pii]
AID - 10.1089/neu.2010.1687 [doi]
PST - ppublish
SO  - J Neurotrauma. 2011 Sep;28(9):1767-82. doi: 10.1089/neu.2010.1687. Epub 2011 Sep 
      6.