PMID- 21896860
OWN - NLM
STAT- MEDLINE
DCOM- 20120105
LR  - 20221207
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 52
IP  - 11
DP  - 2011 Oct 17
TI  - Association of genetic variation on chromosome 9p21 with polypoidal choroidal 
      vasculopathy and neovascular age-related macular degeneration.
PG  - 8063-7
LID - 10.1167/iovs.11-7820 [doi]
AB  - PURPOSE: Polypoidal choroidal vasculopathy (PCV) contains aneurismal morphologic 
      and histopathologic feature and it is considered to be a possible distinct entity 
      from neovascular age-related macular degeneration (AMD). In this study, the 
      association of identified risk variants for intracranial aneurysm on chromosome 
      9p21 with PCV and neovascular AMD in a Chinese Han population was investigated. 
      METHODS: The authors genotyped rs1333040 and rs10757278 on 9p21 in 177 PCV 
      patients, 131 neovascular AMD patients, and 182 controls using a genotyping 
      method and direct DNA sequencing. Allele and genotypes frequencies in the PCV and 
      neovascular AMD groups were compared with controls using a free open-source 
      software and binary logistic regression analysis. RESULTS: Rs1333040 was not 
      associated with PCV or neovascular AMD. Rs10757278 was significantly associated 
      with PCV [risk allele: A, P (allelic) = 0.014; odds ratio = 1.44; 95% confidence 
      interval, 1.08-1.94], but not associated with neovascular AMD. After adjusting 
      for sex, age, smoking status, history of hypertension, type 2 diabetes, and 
      coronary artery disease, the odds ratio for homozygous carriers of rs10757278-A 
      was 2.10 (95% confidence interval, 1.14-3.85) for PCV. CONCLUSIONS: The 
      rs10757278 on chromosome 9p21 is significantly associated with the risk of PCV 
      but not with neovascular AMD in the Chinese Han population.
FAU - Zhang, Xiongze
AU  - Zhang X
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangzhou, China.
FAU - Wen, Feng
AU  - Wen F
FAU - Zuo, Chengguo
AU  - Zuo C
FAU - Li, Meng
AU  - Li M
FAU - Chen, Hui
AU  - Chen H
FAU - Wu, Kunfang
AU  - Wu K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111017
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
RN  - 0 (DNA Primers)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Asian People/genetics
MH  - Choroid Diseases/*genetics
MH  - Chromosomes, Human, Pair 9/*genetics
MH  - DNA Primers/chemistry
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Peripheral Vascular Diseases/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Wet Macular Degeneration/*genetics
EDAT- 2011/09/08 06:00
MHDA- 2012/01/06 06:00
CRDT- 2011/09/08 06:00
PHST- 2011/09/08 06:00 [entrez]
PHST- 2011/09/08 06:00 [pubmed]
PHST- 2012/01/06 06:00 [medline]
AID - iovs.11-7820 [pii]
AID - 10.1167/iovs.11-7820 [doi]
PST - epublish
SO  - Invest Ophthalmol Vis Sci. 2011 Oct 17;52(11):8063-7. doi: 10.1167/iovs.11-7820.