PMID- 21897291
OWN - NLM
STAT- MEDLINE
DCOM- 20120322
LR  - 20161125
IS  - 1473-5598 (Electronic)
IS  - 0263-6352 (Linking)
VI  - 29
IP  - 11
DP  - 2011 Nov
TI  - Normobaric hypoxia conditioning reduces blood pressure and normalizes nitric 
      oxide synthesis in patients with arterial hypertension.
PG  - 2265-72
LID - 10.1097/HJH.0b013e32834b5846 [doi]
AB  - OBJECTIVES: Insufficient production and/or increased decomposition of the potent 
      endogenous vasodilator nitric oxide plays an important role in development and 
      progression of arterial hypertension and its complications. One of the most 
      effective means of stimulating endogenous nitric oxide synthesis is controlled 
      adaptation to hypoxia. This study examined the effect of a 20-day, intermittent, 
      normobaric intermittent hypoxia conditioning (IHC) program on blood pressure (BP) 
      and nitric oxide production in patients with stage 1 arterial hypertension. 
      METHODS: The IHC sessions consisted of four to 10 cycles of alternating 3-min 
      hypoxia (10% FIO2) and 3-min room air breathing. BP was monitored for 24 h before 
      and after IHC, and nitric oxide synthesis was evaluated by 24-h urinary excretion 
      of the stable nitric oxide metabolites nitrate and nitrite. RESULTS: IHC 
      increased nitric oxide synthesis and decreased BP in hypertensive patients to 
      values similar to those of normotensive individuals. Significant inverse 
      correlations were found between nitric oxide production and disease duration, 
      SBP, and DBP. Moreover, IHC enhancement of nitric oxide synthesis was especially 
      robust in patients with arterial hypertension of more than 5 years duration. The 
      reduction in BP persisted for at least 3 months in 28 of 33 hypertensive 
      patients. CONCLUSION: IHC exerted a robust, persistent therapeutic effect and can 
      be considered as an alternative, nonpharmacological treatment for patients with 
      stage 1 arterial hypertension. The antihypertensive action of IHC is associated 
      with normalization of nitric oxide production.
FAU - Lyamina, Nadezhda P
AU  - Lyamina NP
AD  - Saratov Research Institute for Cardiology, Saratov, Russia.
FAU - Lyamina, Svetlana V
AU  - Lyamina SV
FAU - Senchiknin, Valery N
AU  - Senchiknin VN
FAU - Mallet, Robert T
AU  - Mallet RT
FAU - Downey, H Fred
AU  - Downey HF
FAU - Manukhina, Eugenia B
AU  - Manukhina EB
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Hypertens
JT  - Journal of hypertension
JID - 8306882
RN  - 0 (Antihypertensive Agents)
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
CIN - J Hypertens. 2012 Mar;30(3):625-6; author reply 626-7. PMID: 22317999
MH  - Adult
MH  - Antihypertensive Agents/pharmacology
MH  - Blood Pressure
MH  - Blood Pressure Determination/methods
MH  - Case-Control Studies
MH  - Disease Progression
MH  - Humans
MH  - Hypertension/diagnosis/*physiopathology
MH  - *Hypoxia
MH  - Male
MH  - Models, Statistical
MH  - Nitric Oxide/*chemistry/metabolism/urine
MH  - Treatment Outcome
EDAT- 2011/09/08 06:00
MHDA- 2012/03/23 06:00
CRDT- 2011/09/08 06:00
PHST- 2011/09/08 06:00 [entrez]
PHST- 2011/09/08 06:00 [pubmed]
PHST- 2012/03/23 06:00 [medline]
AID - 10.1097/HJH.0b013e32834b5846 [doi]
PST - ppublish
SO  - J Hypertens. 2011 Nov;29(11):2265-72. doi: 10.1097/HJH.0b013e32834b5846.