PMID- 21898045
OWN - NLM
STAT- MEDLINE
DCOM- 20120326
LR  - 20220331
IS  - 1559-1174 (Electronic)
IS  - 1535-1084 (Linking)
VI  - 13
IP  - 4
DP  - 2011 Dec
TI  - Brain-derived neurotrophic factor and Alzheimer's disease: physiopathology and 
      beyond.
PG  - 217-22
LID - 10.1007/s12017-011-8154-x [doi]
AB  - Brain-derived neurotrophic factor (BDNF) is the most widely distributed 
      neurotrophin in the central nervous system where it plays several pivotal roles 
      in synaptic plasticity and neuronal survival. As a consequence, BDNF became a key 
      target in the physiopathology of several neurological and psychiatric diseases. 
      Recent studies have reported altered levels of BDNF in the circulation, i.e. 
      serum or plasma, of patients with Alzheimer's disease (AD), and low BDNF levels 
      in the CSF as predictor of future cognitive decline in healthy older subjects. 
      Altered BDNF circulating levels have also been reported in other 
      neurodegenerative and psychiatric disorders, hampering its use as a specific 
      biomarker for AD. Therefore, BDNF seems to be an unspecific biomarker of 
      neuropsychiatric disorders marked by neurodegenerative changes.
FAU - Diniz, Breno Satler
AU  - Diniz BS
AD  - Laboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, 
      Faculty of Medicine, University of Sao Paulo, Rua Dr. Ovidio Pires de Campos, 785 
      3rd floor, Sao Paulo, SP, 05403-010, Brazil. brenosatler@usp.br
FAU - Teixeira, Antonio Lucio
AU  - Teixeira AL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110907
PL  - United States
TA  - Neuromolecular Med
JT  - Neuromolecular medicine
JID - 101135365
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Alzheimer Disease/blood/cerebrospinal fluid/diagnosis/*physiopathology
MH  - Animals
MH  - Biomarkers
MH  - Brain-Derived Neurotrophic Factor/blood/cerebrospinal fluid/genetics/*physiology
MH  - Disease Models, Animal
MH  - Female
MH  - Humans
MH  - Male
MH  - Mice
MH  - Rats
EDAT- 2011/09/08 06:00
MHDA- 2012/03/27 06:00
CRDT- 2011/09/08 06:00
PHST- 2011/06/26 00:00 [received]
PHST- 2011/08/26 00:00 [accepted]
PHST- 2011/09/08 06:00 [entrez]
PHST- 2011/09/08 06:00 [pubmed]
PHST- 2012/03/27 06:00 [medline]
AID - 10.1007/s12017-011-8154-x [doi]
PST - ppublish
SO  - Neuromolecular Med. 2011 Dec;13(4):217-22. doi: 10.1007/s12017-011-8154-x. Epub 
      2011 Sep 7.