PMID- 21898383
OWN - NLM
STAT- MEDLINE
DCOM- 20120730
LR  - 20211020
IS  - 1097-0215 (Electronic)
IS  - 0020-7136 (Print)
IS  - 0020-7136 (Linking)
VI  - 131
IP  - 2
DP  - 2012 Jul 15
TI  - Increase in circulating levels of IGF-1 and IGF-1/IGFBP-3 molar ratio over a 
      decade is associated with colorectal adenomatous polyps.
PG  - 512-7
LID - 10.1002/ijc.26393 [doi]
AB  - High levels of circulating insulin-like growth factor-1 (IGF-1) have been 
      associated with increased risk of several cancers. Regarding colorectal cancer, 
      these associations are generally weak. We hypothesized that an increase in IGF-1 
      over time would be a stronger risk factor for cancer-related outcomes than the 
      actual levels. In this analysis we utilized existing data from the Insulin 
      Resistance and Atherosclerosis Study (IRAS). Circulating IGF-1 levels and molar 
      ratios of IGF-1 to IGF binding protein 3 (IGFBP-3) were measured at three time 
      points, within a 10-year follow-up period. We examined the associations of 
      increase of the two variables with the presence of colorectal adenoma at the end 
      of follow-up among participants with normal glucose tolerance at baseline. This 
      included 143 individuals, from which 24 were diagnosed with adenomatous polyps. 
      Although the mean levels of IGF-1 and IGF-1/IGFBP-3 decline with age, ~ 30% of 
      the participants showed an increase of at least fifteen percent ("ever increase") 
      in one or both of these variables, compared to baseline. We found a positive 
      association between "ever increase" in IGF-1 or IGF-1/IGFBP-3 and the presence of 
      colorectal adenoma: ORs were 3.81 (95% CI: 1.30-10.8) and 2.83 (95% CI: 
      1.00-8.22), respectively. No association was found when analyzing the actual 
      levels of both variables at any time point. Our data suggest that an increase in 
      circulating IGF-1 or IGF-1/IGFBP-3 may represent a disturbed GH/IGF1 homeostasis, 
      which could favor the development of precancerous lesions such as colorectal 
      adenoma.
CI  - Copyright (c) 2011 UICC.
FAU - Soubry, Adelheid
AU  - Soubry A
AD  - Duke Cancer Institute, Duke University, Durham, NC 27710, USA.
FAU - Il'yasova, Dora
AU  - Il'yasova D
FAU - Sedjo, Rebecca
AU  - Sedjo R
FAU - Wang, Frances
AU  - Wang F
FAU - Byers, Tim
AU  - Byers T
FAU - Rosen, Clifford
AU  - Rosen C
FAU - Yashin, Anatoli
AU  - Yashin A
FAU - Ukraintseva, Svetlana
AU  - Ukraintseva S
FAU - Haffner, Steven
AU  - Haffner S
FAU - D'Agostino, Ralph Jr
AU  - D'Agostino R Jr
LA  - eng
GR  - 1R01CA88007/CA/NCI NIH HHS/United States
GR  - R25 CA126938/CA/NCI NIH HHS/United States
GR  - 5R25-CA126938-02/CA/NCI NIH HHS/United States
GR  - R01 CA088007/CA/NCI NIH HHS/United States
GR  - R01 AG027019/AG/NIA NIH HHS/United States
GR  - R01 DK081028-02/DK/NIDDK NIH HHS/United States
GR  - R01 DK081028/DK/NIDDK NIH HHS/United States
GR  - R01AG027019/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110914
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Adenomatous Polyps/*blood/pathology
MH  - Adult
MH  - Aged
MH  - Colonic Polyps/*blood/pathology
MH  - Colonoscopy
MH  - Colorectal Neoplasms/*blood/pathology
MH  - Female
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Protein 3/biosynthesis/*blood
MH  - Insulin-Like Growth Factor I/*analysis
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
PMC - PMC3314119
MID - NIHMS341520
EDAT- 2011/09/08 06:00
MHDA- 2012/07/31 06:00
PMCR- 2013/07/15
CRDT- 2011/09/08 06:00
PHST- 2011/06/10 00:00 [received]
PHST- 2011/08/04 00:00 [accepted]
PHST- 2011/09/08 06:00 [entrez]
PHST- 2011/09/08 06:00 [pubmed]
PHST- 2012/07/31 06:00 [medline]
PHST- 2013/07/15 00:00 [pmc-release]
AID - 10.1002/ijc.26393 [doi]
PST - ppublish
SO  - Int J Cancer. 2012 Jul 15;131(2):512-7. doi: 10.1002/ijc.26393. Epub 2011 Sep 14.