PMID- 21901235
OWN - NLM
STAT- MEDLINE
DCOM- 20120229
LR  - 20111104
IS  - 2567-689X (Electronic)
IS  - 0340-6245 (Linking)
VI  - 106
IP  - 5
DP  - 2011 Nov
TI  - Dendritic cells in atherosclerosis: functions in immune regulation and beyond.
PG  - 772-8
LID - 10.1160/TH11-05-0296 [doi]
AB  - Chronic inflammation drives the development of atherosclerosis. Dendritic cells 
      (DCs) are known as central mediators of adaptive immune responses and the 
      development of immunological memory and tolerance. DCs are present in 
      non-diseased arteries, and accumulate within atherosclerotic lesions where they 
      can be localised in close vicinity to T cells. Recent work has revealed important 
      functions of DCs in regulating immune mechanisms in atherogenesis, and 
      vaccination strategies using DCs have been explored for treatment of disease. 
      However, in line with a phenotypical and functional overlap with plaque 
      macrophages vascular DCs were also identified to engulf lipids, thus contributing 
      to lipid burden in the vessel wall and initiation of lesion growth. Furthermore, 
      a function of DCs in regulating cholesterol homeostasis has been revealed. 
      Finally, phenotypically distinct plasmacytoid dendritic cells (pDCs) have been 
      identified within atherosclerotic lesions. This review will dissect the 
      multifaceted contribution of DCs and pDCs to the initiation and progression of 
      atherosclerosis and the experimental approaches utilising DCs in therapeutic 
      vaccination strategies.
FAU - Manthey, H D
AU  - Manthey HD
AD  - DFG-Research Center for Experimental Biomedicine, University of 
      Wurzburg,Wurzburg, Germany.
FAU - Zernecke, A
AU  - Zernecke A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110908
PL  - Germany
TA  - Thromb Haemost
JT  - Thrombosis and haemostasis
JID - 7608063
SB  - IM
MH  - Animals
MH  - Arteries/*immunology/metabolism/pathology
MH  - Atherosclerosis/*immunology/metabolism/pathology/therapy
MH  - Dendritic Cells/*immunology/metabolism/pathology/transplantation
MH  - Humans
MH  - Inflammation/*immunology/metabolism/pathology/therapy
MH  - Lipid Metabolism
MH  - Phenotype
MH  - Vaccination/methods
EDAT- 2011/09/09 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/09/09 06:00
PHST- 2011/05/03 00:00 [received]
PHST- 2011/08/02 00:00 [accepted]
PHST- 2011/09/09 06:00 [entrez]
PHST- 2011/09/09 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 11-05-0296 [pii]
AID - 10.1160/TH11-05-0296 [doi]
PST - ppublish
SO  - Thromb Haemost. 2011 Nov;106(5):772-8. doi: 10.1160/TH11-05-0296. Epub 2011 Sep 
      8.