PMID- 21902055
OWN - NLM
STAT- MEDLINE
DCOM- 20111018
LR  - 20190907
IS  - 1028-8880 (Print)
IS  - 1028-8880 (Linking)
VI  - 14
IP  - 7
DP  - 2011 Apr 1
TI  - Growth hormone deficiency in children and adolescents with cerebral palsy: 
      relation to gross motor function and degree of spasticity.
PG  - 433-40
AB  - Children with Cerebral Palsy (CP) often have poor linear growth during childhood 
      with short final height. Thus, we aimed to assess serum growth hormone (GH), 
      insulin like growth factor-1 (IGF-1) and insulin like growth factor binding 
      protein-3 (IGFBP-3) levels among CP patients and their relation to each of gross 
      motor function and degree of spasticity. Fifty CP children and adolescents were 
      studied in comparison to 50 healthy age-, sex- and pubertal stage-matched 
      children and adolescents. All subjects were subjected to clinical evaluation, 
      Intelligence Quotient (IQ) assessment and measurement of serum GH, IGF-1 and 
      IGFBP-3. All auxological and hormonal parameters were significantly lower among 
      cases. Fifty two% of cases were GH-deficient and 62% had reduced IGF-land IGFBP-3 
      levels. Gross Motor Function Measure- 88 (GMFM-88) score correlated negatively 
      with each of basal (r = -0.71, p = 0.02) and peak stimulated GH (r =-0.88, p = 
      <0.001); IGF-1 (r = -0.64, p = 0.04) and IGFBP-3 (r = -0.69, p = 0.031). There 
      were significant negative correlations between the degree of spasticity assessed 
      by Modified Ashworth Scale and each of basal (r = -0.61, p = 0.032) and peak 
      stimulated GH (r = -0.78, p = 0.01); IGF-1 (r = -0.65, p = 0.041) and IGFBP-3 (r 
      = -0.62, p = 0.035). Growth Hormone Deficiency (GHD) is prevalent in children 
      with CP and could be one of the causes of their short stature.
FAU - Hamza, Rasha T
AU  - Hamza RT
AD  - Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, 
      Egypt.
FAU - Ismail, Mona A
AU  - Ismail MA
FAU - Hamed, Amira I
AU  - Hamed AI
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - Pak J Biol Sci
JT  - Pakistan journal of biological sciences : PJBS
JID - 101247723
RN  - 0 (IGFBP3 protein, human)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 0 (Insulin-Like Growth Factor Binding Proteins)
RN  - 12629-01-5 (Human Growth Hormone)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Adolescent
MH  - Case-Control Studies
MH  - Cerebral Palsy/*epidemiology/*physiopathology
MH  - Child
MH  - Child, Preschool
MH  - Comorbidity
MH  - Female
MH  - Gastrointestinal Diseases/epidemiology
MH  - Hemiplegia/epidemiology
MH  - Human Growth Hormone/*deficiency
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Protein 3
MH  - Insulin-Like Growth Factor Binding Proteins/blood
MH  - Insulin-Like Growth Factor I/analysis
MH  - Male
MH  - Mental Disorders/epidemiology
MH  - Muscle Spasticity
MH  - Muscle Weakness/epidemiology
MH  - Psychomotor Performance
MH  - Quadriplegia/epidemiology
MH  - Seizures/epidemiology
EDAT- 2011/09/10 06:00
MHDA- 2011/10/19 06:00
CRDT- 2011/09/10 06:00
PHST- 2011/09/10 06:00 [entrez]
PHST- 2011/09/10 06:00 [pubmed]
PHST- 2011/10/19 06:00 [medline]
AID - 10.3923/pjbs.2011.433.440 [doi]
PST - ppublish
SO  - Pak J Biol Sci. 2011 Apr 1;14(7):433-40. doi: 10.3923/pjbs.2011.433.440.