PMID- 21902584
OWN - NLM
STAT- MEDLINE
DCOM- 20120820
LR  - 20221207
IS  - 1931-8405 (Electronic)
IS  - 0889-2229 (Linking)
VI  - 28
IP  - 6
DP  - 2012 Jun
TI  - HLA-dependent hypersensitivity reaction to nevirapine in Chinese Han HIV-infected 
      patients.
PG  - 540-3
LID - 10.1089/AID.2011.0107 [doi]
AB  - In this study, one hundred and three HIV-positive Chinese Han patients treated 
      with a nevirapine (NVP)-based regimens were investigated for the association 
      between nevirapine hypersensitivity reaction (NVP HSR) and human leukocyte 
      antigen (HLA) allele. HLA-Cw, -DRB1 alleles were determined in 32 NVP HSR cases 
      and 71 NVP-tolerant patients. We found that considerable overlap was observed for 
      the clinical and demographic characteristics of the 32 hypersensitive patients 
      and 71 tolerant patients. Twelve out of 32 NVP HSR cases developed allergic 
      hepatotoxicity. More HLA-Cw*04 alleles were observed in NVP HSR cases than in 
      NVP-tolerant cases (p=0.029). The frequency of HLA-DRB1*15 in NVP-tolerant cases 
      was significant higher than that in NVP HSR cases ( p=0.018). Multivariate 
      logistic regression identified that HLA-Cw*04 presence was a risk factor related 
      to NVP HSR (p=0.030, OR=3.611, 95% CI of OR: 1.135-11.489). To clearly 
      understanding its value in clinical practice, further studies involving larger 
      cohorts of patients from different races with different levels of immune 
      suppression are needed.
FAU - Gao, Shicheng
AU  - Gao S
AD  - Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, 
      Hubei, China.
FAU - Gui, Xi-En
AU  - Gui XE
FAU - Liang, Ke
AU  - Liang K
FAU - Liu, Zhang
AU  - Liu Z
FAU - Hu, Jinzhi
AU  - Hu J
FAU - Dong, Bo
AU  - Dong B
LA  - eng
PT  - Journal Article
DEP - 20111019
PL  - United States
TA  - AIDS Res Hum Retroviruses
JT  - AIDS research and human retroviruses
JID - 8709376
RN  - 0 (Anti-HIV Agents)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 99DK7FVK1H (Nevirapine)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/drug therapy/epidemiology/genetics/*immunology
MH  - Adult
MH  - Alleles
MH  - Anti-HIV Agents/*adverse effects
MH  - Asian People/genetics
MH  - CD4 Lymphocyte Count
MH  - Drug Hypersensitivity/epidemiology/genetics/*immunology
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HLA-C Antigens/genetics/*immunology
MH  - HLA-DRB1 Chains/genetics/*immunology
MH  - Humans
MH  - Male
MH  - Nevirapine/*adverse effects/immunology
MH  - Prevalence
MH  - Risk Factors
EDAT- 2011/09/10 06:00
MHDA- 2012/08/21 06:00
CRDT- 2011/09/10 06:00
PHST- 2011/09/10 06:00 [entrez]
PHST- 2011/09/10 06:00 [pubmed]
PHST- 2012/08/21 06:00 [medline]
AID - 10.1089/AID.2011.0107 [doi]
PST - ppublish
SO  - AIDS Res Hum Retroviruses. 2012 Jun;28(6):540-3. doi: 10.1089/AID.2011.0107. Epub 
      2011 Oct 19.