PMID- 21903151
OWN - NLM
STAT- MEDLINE
DCOM- 20120214
LR  - 20111004
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 504
IP  - 1
DP  - 2011 Oct 17
TI  - Increased apoptosis and different regulation of pro-apoptosis protein bax and 
      anti-apoptosis protein bcl-2 in the olfactory bulb of a rat model of depression.
PG  - 18-22
LID - 10.1016/j.neulet.2011.08.046 [doi]
AB  - Reduced olfactory bulb (OB) volume and olfactory sensitivity have been observed 
      in depressed patients, the exact mechanisms underlying, however, are still 
      unknown. Our previous study found that decreased neurogenesis and pre-synaptic 
      dysfunction in the OB of a rat model of depression may be responsible for the 
      phenomena. Nevertheless, whether the apoptosis would also play a certain role in 
      this process is not clear. In this study, we investigated the apoptosis in the OB 
      of a chronic unpredictable mild stress (CUMS) rat model of depression using 
      terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) 
      staining. Simultaneously, the pro-apoptosis protein bax and anti-apoptosis 
      protein bcl-2 were detected by Western blot. The results showed that the number 
      of TUNEL-positive cells increased dramatically in the glomerular layer of the OB 
      of the CUMS rats, accompanied with up-regulated expression of bax protein and 
      down-regulated expression of bcl-2 protein. The findings indicate that increased 
      apoptosis may be attributed to explain at some level for the reduced OB volume 
      and olfactory dysfunction in depressed patients. Moreover, the 
      mitochondria-dependent death pathway might be involved in apoptosis in the OB of 
      the CUMS rats.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Yang, Deyu
AU  - Yang D
AD  - Department of Neurology, The First Affiliated Hospital, Chongqing Medical 
      University, Chongqing, China.
FAU - Liu, Xia
AU  - Liu X
FAU - Zhang, Rufang
AU  - Zhang R
FAU - Cheng, Ke
AU  - Cheng K
FAU - Mu, Jun
AU  - Mu J
FAU - Fang, Liang
AU  - Fang L
FAU - Xie, Peng
AU  - Xie P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110827
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
RN  - 0 (bcl-2-Associated X Protein)
SB  - IM
MH  - Animals
MH  - Apoptosis/*physiology
MH  - Depression/*metabolism/*physiopathology
MH  - Disease Models, Animal
MH  - Gene Expression Regulation
MH  - Humans
MH  - Male
MH  - Olfactory Bulb/*metabolism/*physiopathology
MH  - Proto-Oncogene Proteins c-bcl-2/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Stress, Psychological/metabolism/physiopathology
MH  - bcl-2-Associated X Protein/*metabolism
EDAT- 2011/09/10 06:00
MHDA- 2012/02/15 06:00
CRDT- 2011/09/10 06:00
PHST- 2011/03/20 00:00 [received]
PHST- 2011/08/07 00:00 [revised]
PHST- 2011/08/22 00:00 [accepted]
PHST- 2011/09/10 06:00 [entrez]
PHST- 2011/09/10 06:00 [pubmed]
PHST- 2012/02/15 06:00 [medline]
AID - S0304-3940(11)01231-6 [pii]
AID - 10.1016/j.neulet.2011.08.046 [doi]
PST - ppublish
SO  - Neurosci Lett. 2011 Oct 17;504(1):18-22. doi: 10.1016/j.neulet.2011.08.046. Epub 
      2011 Aug 27.