PMID- 21903259
OWN - NLM
STAT- MEDLINE
DCOM- 20120120
LR  - 20110919
IS  - 1878-5905 (Electronic)
IS  - 0142-9612 (Linking)
VI  - 32
IP  - 33
DP  - 2011 Nov
TI  - Single nonfouling hydrogels with mechanical and chemical functionality gradients.
PG  - 8456-61
LID - 10.1016/j.biomaterials.2011.07.062 [doi]
AB  - Hydrogels are widely studied as tissue engineering scaffolds, but the biological 
      tissues they are designed to mimic are often complex tissues with non-uniform 
      chemical and mechanical profiles. This work reports a new strategy to create 
      hydrogels composed of a continuous sheet of a single nonfouling but 
      functionalizable material with mechanical and/or chemical functionality 
      gradients. By using different combinations of functionalizable or 
      nonfunctionalizable versions of nonfouling carboxybetaine methacrylate (CBMA) and 
      carboxybetaine dimethacrylate crosslinker (CBMAX), various hydrogels with 
      gradients of crosslinking densities and/or functionalizable groups can be 
      created. In this work, we demonstrate this concept with two nonfouling hydrogels, 
      both with a mechanical gradient: one with uniform functionalizability and the 
      other with a gradient in chemical functionalizability. With this versatile 
      system, hydrogels with built-in gradient profiles of various types can be 
      controlled at will for a given application.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Carr, Louisa R
AU  - Carr LR
AD  - Department of Chemical Engineering, University of Washington, Box 351750, 
      Seattle, WA 98195, USA.
FAU - Krause, Jordan E
AU  - Krause JE
FAU - Ella-Menye, Jean-Rene
AU  - Ella-Menye JR
FAU - Jiang, Shaoyi
AU  - Jiang S
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20110907
PL  - Netherlands
TA  - Biomaterials
JT  - Biomaterials
JID - 8100316
RN  - 0 (Hydrogels)
SB  - IM
MH  - *Hydrogels
EDAT- 2011/09/10 06:00
MHDA- 2012/01/21 06:00
CRDT- 2011/09/10 06:00
PHST- 2011/07/04 00:00 [received]
PHST- 2011/07/20 00:00 [accepted]
PHST- 2011/09/10 06:00 [entrez]
PHST- 2011/09/10 06:00 [pubmed]
PHST- 2012/01/21 06:00 [medline]
AID - S0142-9612(11)00859-3 [pii]
AID - 10.1016/j.biomaterials.2011.07.062 [doi]
PST - ppublish
SO  - Biomaterials. 2011 Nov;32(33):8456-61. doi: 10.1016/j.biomaterials.2011.07.062. 
      Epub 2011 Sep 7.