PMID- 2190326
OWN - NLM
STAT- MEDLINE
DCOM- 19900712
LR  - 20131121
IS  - 0371-0874 (Print)
IS  - 0371-0874 (Linking)
VI  - 42
IP  - 1
DP  - 1990 Feb
TI  - [Preliminary studies on the relationship between the blood pressure and 
      renin-angiotensin system in brain and blood vessels in SHRSP].
PG  - 61-7
AB  - This work analyzed the relationship between A I concentration in aorta tissue and 
      systolic blood pressure (SBP) in stroke-prone spontaneously hypertensive rats 
      (SHRSP) at different ages. The SBP of SHRSP increased progressively with the age 
      until the age of 20 weeks, when the SBP of SHRSP no longer elevated but sustained 
      at a relatively high and stable level. The A I concentration in aorta of SHRSP 
      was much higher than that of Wistar Kyoto rats at all of the three different 
      ages. Perfusion of captopril into the lateral cerebroventricle of SHRSP for four 
      weeks evoked a considerable decrease of A I concentration in brain as well as a 
      significant reduction of SBP accompanied by a decrement of A I concentration in 
      aorta and concentration of norepinephrine and epinephrine in aorta tissue and 
      plasma. The results further confirm the close relationship between the changed 
      activity of renin-angiotensin system localized in blood vessels during 
      hypertension and the pathogenesis of hypertension, and indicate the possible 
      regulative control of A I generated from central nervous system over the 
      production of A I from blood vessels by means of facilitating the activity of 
      peripheral sympathetic nerve system.
FAU - Ding, H
AU  - Ding H
AD  - Department of Physiology, Tongji Medical University, Wuhan.
FAU - Zhou, Q
AU  - Zhou Q
FAU - Deng, J
AU  - Deng J
FAU - Lo, H Y
AU  - Lo HY
FAU - Yang, K
AU  - Yang K
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Sheng Li Xue Bao
JT  - Sheng li xue bao : [Acta physiologica Sinica]
JID - 20730130R
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 11128-99-7 (Angiotensin II)
RN  - 9G64RSX1XD (Captopril)
RN  - X4W3ENH1CV (Norepinephrine)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Angiotensin II/*metabolism
MH  - Angiotensin-Converting Enzyme Inhibitors
MH  - Animals
MH  - Aorta/*metabolism
MH  - *Blood Pressure
MH  - Brain/*metabolism
MH  - Captopril/pharmacology
MH  - Epinephrine/analysis
MH  - Male
MH  - Norepinephrine/analysis
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Renin-Angiotensin System/*physiology
EDAT- 1990/02/01 00:00
MHDA- 1990/02/01 00:01
CRDT- 1990/02/01 00:00
PHST- 1990/02/01 00:00 [pubmed]
PHST- 1990/02/01 00:01 [medline]
PHST- 1990/02/01 00:00 [entrez]
PST - ppublish
SO  - Sheng Li Xue Bao. 1990 Feb;42(1):61-7.