PMID- 21903320
OWN - NLM
STAT- MEDLINE
DCOM- 20130418
LR  - 20220317
IS  - 1579-2129 (Electronic)
IS  - 0300-2896 (Linking)
VI  - 47
IP  - 10
DP  - 2011 Oct
TI  - Advances in the diagnosis of tuberculosis infection.
PG  - 521-30
LID - 10.1016/j.arbres.2011.06.018 [doi]
AB  - One-third of the world-wide population currently presents latent tuberculosis 
      infection (LTI). In Spain, TB is situated as the third disease of mandatory 
      notification. The standard technique for the diagnosis of ITL is the tuberculin 
      test (PPD), although its most important drawback is its specificity since the 
      proteins used are not specific for Mycobacterium tuberculosis. In recent years, 
      research has been done and new diagnostic methods have been approved based on the 
      in vitro quantification of the immune cell response, the so-called interferon 
      gamma release assays (IGRA). Compared with PPD, the main difference is that IGRAs 
      detect the release of interferon-gamma in response to specific tuberculous 
      antigens. In the absence of a true reference test for the diagnosis of 
      tuberculosis infection, it is difficult to establish the sensitivity and 
      specificity of these new diagnostic techniques. IGRAs have been used in the 
      detection of ITL in subjects with immune system alterations (HIV, EEI, IRC, 
      rheumatologic diseases) with good results. They are also being extensively used 
      in the study of contacts. In recent studies involving serial controls of said 
      tests, they were observed to present conversions and reversions that occur after 
      exposure to M. tuberculosis. Today and with the current knowledge, it seems that 
      IGRAs can complement PPD, but not substitute them.
CI  - Copyright (c) 2010 SEPAR. Published by Elsevier Espana. All rights reserved.
FAU - Arias Guillen, Miguel
AU  - Arias Guillen M
AD  - Servicio de Neumologia, Hospital Universitario Central de Asturias-Instituto 
      Nacional de Silicosis, Oviedo, Espana. MIGUELARIASGUILLEN@gmail.com
LA  - eng
LA  - spa
PT  - Journal Article
PT  - Review
DEP - 20110907
PL  - Spain
TA  - Arch Bronconeumol
JT  - Archivos de bronconeumologia
JID - 0354720
SB  - IM
MH  - Decision Trees
MH  - Humans
MH  - Tuberculosis, Pulmonary/*diagnosis/immunology
EDAT- 2011/09/10 06:00
MHDA- 2013/04/20 06:00
CRDT- 2011/09/10 06:00
PHST- 2010/09/20 00:00 [received]
PHST- 2011/06/03 00:00 [revised]
PHST- 2011/06/11 00:00 [accepted]
PHST- 2011/09/10 06:00 [entrez]
PHST- 2011/09/10 06:00 [pubmed]
PHST- 2013/04/20 06:00 [medline]
AID - S0300-2896(11)00232-8 [pii]
AID - 10.1016/j.arbres.2011.06.018 [doi]
PST - ppublish
SO  - Arch Bronconeumol. 2011 Oct;47(10):521-30. doi: 10.1016/j.arbres.2011.06.018. 
      Epub 2011 Sep 7.