PMID- 21904547
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20231105
IS  - 1687-8345 (Electronic)
IS  - 1687-8337 (Linking)
VI  - 2011
DP  - 2011
TI  - Moderate weight reduction in an outpatient obesity intervention program 
      significantly reduces insulin resistance and risk factors for cardiovascular 
      disease in severely obese adolescents.
PG  - 541021
LID - 10.1155/2011/541021 [doi]
AB  - Background. Metabolic risk factors like insulin resistance and dyslipidemia are 
      frequently observed in severly obese children. We investigated the hypothesis 
      that moderate weight reduction by a low-threshold intervention is already able to 
      reduce insulin resistance and cardiovascular risk factors in severely obese 
      children. Methods. A group of 58 severely obese children and adolescents between 
      8 and 17 years participating in a six-month-long outpatient program was studied 
      before and after treatment. The program included behavioral treatment, dietary 
      education and specific physical training. Metabolic parameters were measured in 
      the fasting state, insulin resistance was evaluated in an oral glucose tolerance 
      test. Results. Mean standard deviation score of the body mass index (SDS-BMI) in 
      the study group dropped significantly from +2.5 +/- 0.5 to 2.3 +/- 0.6 (P < 0.0001) 
      after participation in the program. A significant decrease was observed in HOMA 
      (6.3 +/- 4.2 versus 4.9 +/- 2.4, P < 0.03, and in peak insulin levels (232.7 +/- 132.4 
      versus 179.2 +/- 73.3 muU/mL, P < 0.006). Significant reductions were also observed 
      in mean levels of hemoglobin A(1c), total cholesterol and LDL cholesterol. 
      Conclusions. These data demonstrate that already moderate weight reduction is 
      able to decrease insulin resistance and dyslipidemia in severely obese children 
      and adolescents.
FAU - Grulich-Henn, J
AU  - Grulich-Henn J
AD  - Department of Pediatrics, University of Heidelberg, INF 430, 69120 Heidelberg, 
      Germany.
FAU - Lichtenstein, S
AU  - Lichtenstein S
FAU - Horster, F
AU  - Horster F
FAU - Hoffmann, G F
AU  - Hoffmann GF
FAU - Nawroth, P P
AU  - Nawroth PP
FAU - Hamann, A
AU  - Hamann A
LA  - eng
PT  - Journal Article
DEP - 20110822
PL  - Egypt
TA  - Int J Endocrinol
JT  - International journal of endocrinology
JID - 101516376
PMC - PMC3166723
EDAT- 2011/09/10 06:00
MHDA- 2011/09/10 06:01
CRDT- 2011/09/10 06:00
PHST- 2011/01/27 00:00 [received]
PHST- 2011/05/23 00:00 [revised]
PHST- 2011/06/24 00:00 [accepted]
PHST- 2011/09/10 06:00 [entrez]
PHST- 2011/09/10 06:00 [pubmed]
PHST- 2011/09/10 06:01 [medline]
AID - 10.1155/2011/541021 [doi]
PST - ppublish
SO  - Int J Endocrinol. 2011;2011:541021. doi: 10.1155/2011/541021. Epub 2011 Aug 22.