PMID- 21904775
OWN - NLM
STAT- MEDLINE
DCOM- 20120120
LR  - 20131121
IS  - 1791-2423 (Electronic)
IS  - 1019-6439 (Linking)
VI  - 40
IP  - 1
DP  - 2012 Jan
TI  - Novel anti-cancer role of naphthazarin in human gastric cancer cells.
PG  - 157-62
LID - 10.3892/ijo.2011.1195 [doi]
AB  - Gastric cancer is one of the most common malignant tumors and the second cause of 
      cancer-related deaths worldwide. Naphthoquinones such as juglone and plumbagin 
      are compounds used extensively to overcome resistance to chemotherapeutic agents 
      in cancers due to their cytotoxic role. This study is the first to investigate 
      the anti-cancer effect of naphthazarin (Naph), one of the naphthaquinones, in 
      human gastric cancer AGS cells. We showed that Naph exhibited effective 
      preferential cell growth inhibition via G2/M phase arrest and apoptosis, which 
      was associated with reduced levels of Cdc2 and Cdc25C expression. Naph also 
      increased cleaved caspase-3 and Poly ADR(adenosine diphosphate ribose) Polymerase 
      expression, gamma-H2AX expression (an indicator of DNA double strand breaks) and DNA 
      fragmentation. We also found the generation of reactive oxygen species is a 
      critical mediator in Naph-induced cell growth inhibition and apoptosis. The 
      non-protein antioxidant, glutathione significantly abolished Naph-mediated 
      inhibition of cell growth and apoptosis. Taken together, our findings showed that 
      Naph not only inhibited cell growth, but also induced apoptosis of AGS cells, 
      suggesting that Naph may be a potential candidate for cancer therapy against 
      gastric cancers.
FAU - Kim, Jin-Ah
AU  - Kim JA
AD  - Research Center, Dongnam Institute of Radiological and Medical Science, 40 
      Jwadong-gil, Jangan-eup, Gijang-gun, Busan 619-953, Republic of Korea.
FAU - Lee, Eun Kyeong
AU  - Lee EK
FAU - Park, Seong Joon
AU  - Park SJ
FAU - Kim, Nam Deuk
AU  - Kim ND
FAU - Hyun, Dong-Hoon
AU  - Hyun DH
FAU - Lee, Chang Geun
AU  - Lee CG
FAU - Lee, Jae Ho
AU  - Lee JH
FAU - Yang, Kwang Mo
AU  - Yang KM
FAU - Heo, Kyu
AU  - Heo K
FAU - Son, Tae Gen
AU  - Son TG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110908
PL  - Greece
TA  - Int J Oncol
JT  - International journal of oncology
JID - 9306042
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Naphthoquinones)
RN  - 0 (Reactive Oxygen Species)
RN  - 475-38-7 (naphthazarin)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Antineoplastic Agents/*pharmacology
MH  - Apoptosis/drug effects/physiology
MH  - Cell Cycle/drug effects/physiology
MH  - Cell Line, Tumor
MH  - Glutathione/metabolism
MH  - Humans
MH  - Naphthoquinones/*pharmacology
MH  - Oxidative Stress/drug effects
MH  - Reactive Oxygen Species/metabolism
MH  - Stomach Neoplasms/*drug therapy/metabolism/pathology
EDAT- 2011/09/10 06:00
MHDA- 2012/01/21 06:00
CRDT- 2011/09/10 06:00
PHST- 2011/07/05 00:00 [received]
PHST- 2011/08/17 00:00 [accepted]
PHST- 2011/09/10 06:00 [entrez]
PHST- 2011/09/10 06:00 [pubmed]
PHST- 2012/01/21 06:00 [medline]
AID - 10.3892/ijo.2011.1195 [doi]
PST - ppublish
SO  - Int J Oncol. 2012 Jan;40(1):157-62. doi: 10.3892/ijo.2011.1195. Epub 2011 Sep 8.