PMID- 21905256
OWN - NLM
STAT- MEDLINE
DCOM- 20120117
LR  - 20151119
IS  - 2151-4658 (Electronic)
IS  - 2151-464X (Linking)
VI  - 63
IP  - 12
DP  - 2011 Dec
TI  - Association between skeletal muscle inflammatory markers and walking pattern in 
      people with knee osteoarthritis.
PG  - 1715-21
LID - 10.1002/acr.20625 [doi]
AB  - OBJECTIVE: Patients with knee osteoarthritis (OA) are characterized by increased 
      muscle inflammation and altered gait. We investigated the association between 
      proinflammatory mediators in the vastus lateralis and physical function and gait 
      in patients with knee OA. METHODS: Nineteen patients with knee OA underwent gait 
      analysis, assessment of self-reported pain and physical function (Western Ontario 
      and McMaster Universities Osteoarthritis Index [WOMAC]), and a muscle biopsy that 
      was taken during their knee replacement surgery. Muscle was analyzed for cellular 
      protein inflammatory mediators, interleukin-6, monocyte chemotactic protein 1 
      (MCP-1), p65 NF-kappaB, signal transducer and activator of transcription 3 (STAT-3), 
      and JNK-1. Sagittal plane knee function, including early stance knee range of 
      motion (ROM) and knee sagittal plane impulse, was measured using a motion 
      analysis system. Pearson's correlation was used to assess relationships between 
      selected variables. RESULTS: Significant positive correlations were found between 
      MCP-1 and self-perceived stiffness, physical function, and the total WOMAC score 
      (P < 0.05). MCP-1 was also negatively correlated with early stance knee ROM (r = 
      -0.52, P = 0.023). Reduced velocity was associated with elevated levels of p65 
      NF-kappaB and STAT-3 (P < 0.05). Knee sagittal plane impulse was negatively 
      correlated with JNK-1 (P = 0.02), indicating reduction in knee impulse with an 
      increased level of JNK-1. CONCLUSION: Increased levels of several proinflammatory 
      mediators were correlated with altered knee function during walking as well as 
      greater physical disability and slower gait velocity. Identification of the 
      cellular and molecular mechanisms associated with muscle inflammation is 
      important to better understand the underlying mechanism responsible for altered 
      gait and function in patients with knee OA.
CI  - Copyright (c) 2011 by the American College of Rheumatology.
FAU - Levinger, Pazit
AU  - Levinger P
AD  - La Trobe University, Bundoora, Victoria, Australia. p.levinger@latrobe.edu.au
FAU - Caldow, Marissa K
AU  - Caldow MK
FAU - Feller, Julian A
AU  - Feller JA
FAU - Bartlett, John R
AU  - Bartlett JR
FAU - Bergman, Neil R
AU  - Bergman NR
FAU - McKenna, Michael J
AU  - McKenna MJ
FAU - Cameron-Smith, David
AU  - Cameron-Smith D
FAU - Levinger, Itamar
AU  - Levinger I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Arthritis Care Res (Hoboken)
JT  - Arthritis care & research
JID - 101518086
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (IL6 protein, human)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Interleukin-6)
RN  - 0 (RELA protein, human)
RN  - 0 (STAT3 Transcription Factor)
RN  - 0 (STAT3 protein, human)
RN  - 0 (Transcription Factor RelA)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 8)
SB  - IM
MH  - Aged
MH  - Biomarkers/analysis
MH  - Biomechanical Phenomena
MH  - Biopsy
MH  - Chemokine CCL2/analysis
MH  - Cross-Sectional Studies
MH  - Disability Evaluation
MH  - Female
MH  - *Gait
MH  - Humans
MH  - Inflammation Mediators/*analysis
MH  - Interleukin-6/analysis
MH  - Male
MH  - Middle Aged
MH  - Mitogen-Activated Protein Kinase 8/analysis
MH  - Osteoarthritis, Knee/diagnosis/*immunology/*physiopathology
MH  - Pain Measurement
MH  - Quadriceps Muscle/*immunology/*physiopathology
MH  - Range of Motion, Articular
MH  - STAT3 Transcription Factor/analysis
MH  - Self Report
MH  - Transcription Factor RelA/analysis
MH  - Victoria
MH  - *Walking
EDAT- 2011/09/10 06:00
MHDA- 2012/01/18 06:00
CRDT- 2011/09/10 06:00
PHST- 2011/09/10 06:00 [entrez]
PHST- 2011/09/10 06:00 [pubmed]
PHST- 2012/01/18 06:00 [medline]
AID - 10.1002/acr.20625 [doi]
PST - ppublish
SO  - Arthritis Care Res (Hoboken). 2011 Dec;63(12):1715-21. doi: 10.1002/acr.20625.