PMID- 21907415
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20220408
IS  - 1549-4713 (Electronic)
IS  - 0161-6420 (Linking)
VI  - 118
IP  - 12
DP  - 2011 Dec
TI  - Variation in optic nerve and macular structure with age and race with 
      spectral-domain optical coherence tomography.
PG  - 2403-8
LID - 10.1016/j.ophtha.2011.06.013 [doi]
AB  - PURPOSE: To evaluate the effects of age and race on optic disc, retinal nerve 
      fiber layer (RNFL), and macular measurements with spectral-domain optical 
      coherence tomography (SD OCT). DESIGN: Cross-sectional observational study. 
      PARTICIPANTS: Three hundred fifty adult subjects without ocular disease. METHODS: 
      Data from SD OCT imaging of the optic nerve head, peripapillary RNFL, and macula 
      of 632 eyes from 350 subjects without ocular disease were imaged with SD OCT. 
      Multivariate models were used to determine the effect of age and race on 
      quantitative measurements of optic disc, RNFL, and macula. MAIN OUTCOME MEASURES: 
      Optic nerve, RNFL, and macular measurements with SD OCT across racial strata and 
      age. RESULTS: For optic nerve parameters, participants of European descent had 
      significantly smaller optic disc area than other groups (P<0.0001), and Indian 
      participants had significantly smaller rim area than other groups (P<0.0001). 
      Indian and Hispanic participants had thicker global RNFL measurements than other 
      groups (P<0.0001). Participants of African descent were associated with thinner 
      inner retinal thickness in the macula (P<0.0001). Age was associated with several 
      parameters, with rim area reducing by 0.005 mm(2)/year, RNFL thickness reducing 
      by 0.18 mum/year, and inner retinal thickness reducing by 0.1 mum/year (P<0.0001 
      for all age associations). CONCLUSIONS: Optic nerve, RNFL, and macular 
      measurements with SD OCT all varied across racial groups and with age. These 
      differences are important in defining the range of normal variation in differing 
      populations and should be considered in the use of these instruments in the 
      detection of optic nerve and macular disease across these population groups. 
      FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found after 
      the references.
CI  - Copyright (c) 2011 American Academy of Ophthalmology. Published by Elsevier Inc. 
      All rights reserved.
FAU - Girkin, Christopher A
AU  - Girkin CA
AD  - Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, 
      Alabama 35233, USA. cgirkin@uab.edu
FAU - McGwin, Gerald Jr
AU  - McGwin G Jr
FAU - Sinai, Micheal J
AU  - Sinai MJ
FAU - Sekhar, G Chandra
AU  - Sekhar GC
FAU - Fingeret, Murrey
AU  - Fingeret M
FAU - Wollstein, Gadi
AU  - Wollstein G
FAU - Varma, Rohit
AU  - Varma R
FAU - Greenfield, David
AU  - Greenfield D
FAU - Liebmann, Jeffery
AU  - Liebmann J
FAU - Araie, Makoto
AU  - Araie M
FAU - Tomita, Goji
AU  - Tomita G
FAU - Maeda, Naoyuki
AU  - Maeda N
FAU - Garway-Heath, David F
AU  - Garway-Heath DF
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20110909
PL  - United States
TA  - Ophthalmology
JT  - Ophthalmology
JID - 7802443
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*physiology
MH  - Body Weights and Measures
MH  - Cross-Sectional Studies
MH  - Ethnicity
MH  - Female
MH  - Humans
MH  - Intraocular Pressure/physiology
MH  - Macula Lutea/*anatomy & histology
MH  - Male
MH  - Middle Aged
MH  - *Nerve Fibers
MH  - Optic Disk/*anatomy & histology
MH  - Prospective Studies
MH  - *Racial Groups
MH  - Retinal Ganglion Cells/*cytology
MH  - *Tomography, Optical Coherence
MH  - Visual Acuity/physiology
MH  - Young Adult
EDAT- 2011/09/13 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/09/13 06:00
PHST- 2011/02/04 00:00 [received]
PHST- 2011/06/10 00:00 [revised]
PHST- 2011/06/14 00:00 [accepted]
PHST- 2011/09/13 06:00 [entrez]
PHST- 2011/09/13 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - S0161-6420(11)00556-2 [pii]
AID - 10.1016/j.ophtha.2011.06.013 [doi]
PST - ppublish
SO  - Ophthalmology. 2011 Dec;118(12):2403-8. doi: 10.1016/j.ophtha.2011.06.013. Epub 
      2011 Sep 9.