PMID- 21908652
OWN - NLM
STAT- MEDLINE
DCOM- 20120213
LR  - 20111020
IS  - 1092-874X (Electronic)
IS  - 1091-5818 (Linking)
VI  - 30
IP  - 5
DP  - 2011 Oct
TI  - Antiasthmatic effects of Gleditsia sinensis in an ovalbumin-induced murine model 
      of asthma.
PG  - 528-37
LID - 10.1177/1091581811412398 [doi]
AB  - This study evaluated the antiasthmatic effects of Gleditsia sinensis ethanolic 
      extract (GSEE) and its underlying mechanisms, using an in vivo murine model of 
      asthma. Female BALB/c mice were sensitized, challenged with ovalbumin, and then 
      examined for asthmatic reactions. The results showed that GSEE exerted profound 
      inhibitory effects on the accumulation of eosinophils in the airways and reduced 
      the levels of interleukin (IL)-4 and IL-5 in bronchoalveolar lavage fluid (BALF) 
      and immunoglobulin E (IgE) in BALF and plasma. Gleditsia sinensis ethanolic 
      extract also suppressed the production of reactive oxygen species in BALF and 
      inflammatory infiltration, in a dose-dependent manner, and it inhibited 
      goblet-cell hyperplasia in lung tissue. Thus, GSEE shows antiasthmatic effects in 
      a murine model of allergic asthma, which appeared to be mediated partially by the 
      reduction of oxidative stress and airway inflammation. These results indicate 
      that GSEE could be an effective novel therapeutic agent for the treatment of 
      allergic asthma.
FAU - Lee, Mee-Young
AU  - Lee MY
AD  - Herbal Medicine EBM Research Center, Korea Institute of Oriental Medicine, 
      Yusung-gu, Daejeon, Republic of Korea.
FAU - Shin, In-Sik
AU  - Shin IS
FAU - Seo, Chang-Seob
AU  - Seo CS
FAU - Ha, Heykyung
AU  - Ha H
FAU - Shin, Hyeun-Kyoo
AU  - Shin HK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110909
PL  - United States
TA  - Int J Toxicol
JT  - International journal of toxicology
JID - 9708436
RN  - 0 (Anti-Asthmatic Agents)
RN  - 0 (Interleukin-5)
RN  - 0 (Plant Extracts)
RN  - 0 (Reactive Oxygen Species)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - Anti-Asthmatic Agents/pharmacokinetics/*pharmacology
MH  - Asthma/*chemically induced/*drug therapy
MH  - Bronchoalveolar Lavage Fluid
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Eosinophils/metabolism
MH  - Female
MH  - Gleditsia/*chemistry
MH  - Goblet Cells/drug effects
MH  - Immunoglobulin E/blood
MH  - Inflammation/drug therapy
MH  - Interleukin-4/blood
MH  - Interleukin-5/blood
MH  - Lung/drug effects
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Ovalbumin/*toxicity
MH  - Plant Extracts/pharmacokinetics/*pharmacology
MH  - Reactive Oxygen Species/antagonists & inhibitors
EDAT- 2011/09/13 06:00
MHDA- 2012/02/14 06:00
CRDT- 2011/09/13 06:00
PHST- 2011/09/13 06:00 [entrez]
PHST- 2011/09/13 06:00 [pubmed]
PHST- 2012/02/14 06:00 [medline]
AID - 1091581811412398 [pii]
AID - 10.1177/1091581811412398 [doi]
PST - ppublish
SO  - Int J Toxicol. 2011 Oct;30(5):528-37. doi: 10.1177/1091581811412398. Epub 2011 
      Sep 9.