PMID- 21908890 OWN - NLM STAT- MEDLINE DCOM- 20120529 LR - 20211020 IS - 1569-9285 (Electronic) IS - 1569-9285 (Linking) VI - 13 IP - 6 DP - 2011 Dec TI - Systemic levels of endothelin correlate with systemic inflammation and not with myocardial injury or left ventricular ejection fraction in patients undergoing percutaneous coronary intervention and on-pump coronary artery bypass grafting. PG - 585-9 LID - 10.1510/icvts.2011.278192 [doi] AB - Endothelin (ET-1) is a potent vasoconstrictor. We compared patterns of ET-1 in percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and correlated it with markers of inflammation. Patients with multivessel disease were enrolled in a prospective randomized study of PCI vs. on-pump CABG. Procedural myocardial injury was assessed biochemically (CK-MB) and with new late gadolinium enhancement (LGE) on magnetic resonance imaging (MRI) one week postprocedure. ET-1 was measured at baseline, 1 h, 6 h, 12 h, 24 h and one week postprocedure. Log ET-1 values were compared between PCI and CABG and between patients without significant myocardial injury. Measurement of ET-1 values was performed in 36 PCI and 31 CABG patients. Baseline ET-1 values were similar between PCI and CABG patients (0.91 +/- 0.36 vs. 1.0 +/- 49 pg/ml, P = 0.38). Peak values were reached at 1 h in PCI and at 24 h in CABG patients and patients undergoing CABG had significantly higher log ET-1 values at 6 h, 12 h and 24 h. ET-1 did not correlate with biochemical or morphological markers of myocardial injury or change of left ventricular ejection fraction (LV-EF) but good linear correlation between max logET-1 and max logCRP was found (r = 0.44, P = 0.0002). ET-1 rise is more pronounced in on-pump CABG and ET-1 production could be driven by periprocedural inflammatory reaction. FAU - Cuculi, Florim AU - Cuculi F AD - Oxford Heart Centre, John Radcliffe Hospital, Oxford OX3 9DU, UK. FAU - Lim, Chris C S AU - Lim CC FAU - van Gaal, William AU - van Gaal W FAU - Testa, Luca AU - Testa L FAU - Westaby, Stephen AU - Westaby S FAU - Arnold, Jayanth R AU - Arnold JR FAU - Neubauer, Stefan AU - Neubauer S FAU - Banning, Adrian P AU - Banning AP LA - eng SI - ISRCTN/ISRCTN25699844 GR - 090532/Wellcome Trust/United Kingdom GR - MRC_/Medical Research Council/United Kingdom PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20110911 PL - England TA - Interact Cardiovasc Thorac Surg JT - Interactive cardiovascular and thoracic surgery JID - 101158399 RN - 0 (Biomarkers) RN - 0 (Contrast Media) RN - 0 (Endothelin-1) RN - 0 (Inflammation Mediators) RN - 0 (Troponin I) RN - EC 2.7.3.2 (Creatine Kinase, MB Form) SB - IM CIN - Interact Cardiovasc Thorac Surg. 2011 Dec;13(6):589-90. PMID: 22144647 MH - Aged MH - Analysis of Variance MH - Angioplasty, Balloon, Coronary/*adverse effects MH - Biomarkers/blood MH - Cardiopulmonary Bypass/*adverse effects MH - Chi-Square Distribution MH - Contrast Media MH - Coronary Artery Bypass/*adverse effects MH - Coronary Artery Disease/blood/physiopathology/surgery/*therapy MH - Creatine Kinase, MB Form/blood MH - Endothelin-1/*blood MH - England MH - Female MH - Humans MH - Inflammation/blood/*etiology/immunology MH - Inflammation Mediators/*blood MH - Magnetic Resonance Imaging MH - Male MH - Middle Aged MH - Myocardial Infarction/blood/*etiology/pathology/physiopathology MH - Myocardium/pathology MH - Predictive Value of Tests MH - Prospective Studies MH - Stroke Volume MH - Time Factors MH - Treatment Outcome MH - Troponin I/blood MH - Up-Regulation MH - *Ventricular Function, Left EDAT- 2011/09/13 06:00 MHDA- 2012/05/30 06:00 CRDT- 2011/09/13 06:00 PHST- 2011/09/13 06:00 [entrez] PHST- 2011/09/13 06:00 [pubmed] PHST- 2012/05/30 06:00 [medline] AID - icvts.2011.278192 [pii] AID - 10.1510/icvts.2011.278192 [doi] PST - ppublish SO - Interact Cardiovasc Thorac Surg. 2011 Dec;13(6):585-9. doi: 10.1510/icvts.2011.278192. Epub 2011 Sep 11.