PMID- 21908933
OWN - NLM
STAT- MEDLINE
DCOM- 20120605
LR  - 20190907
IS  - 1348-4540 (Electronic)
IS  - 0918-8959 (Linking)
VI  - 58
IP  - 11
DP  - 2011
TI  - Crosstalk of thyroid hormone receptor and liver X receptor in lipid metabolism 
      and beyond [Review].
PG  - 921-30
AB  - Thyroid hormone receptors (TRs) and liver X receptors (LXRs) are members of the 
      nuclear receptor superfamily. Although LXRs and TRs belong to two distinct 
      receptor subgroups with respect to ligand-binding affinity, the two receptor 
      systems show similarity with respect to molecular mechanism, target genes, and 
      physiological roles. Since both TRs and LXRs play an important role in metabolic 
      regulation, form heterodimers with retinoid X receptors (RXRs), and bind to 
      direct repeat-4 (DR-4) with identical geometry and polarity, crosstalk between 
      these two receptors has been reported, especially on lipid metabolism-related 
      genes. Recently, several types of crosstalk between TRs and LXRs have been 
      identified and crosstalk has also been observed in other physiological systems 
      such as central nervous system rather than lipid metabolism. In this review, 
      recent advances in elucidating the molecular mechanisms of the crosstalk between 
      these two nuclear receptors are discussed, with the aim of finding a perspective 
      on unknown roles of TRs and LXRs.
FAU - Hashimoto, Koshi
AU  - Hashimoto K
AD  - Department of Medicine and Molecular Science, Gunma University Graduate School of 
      Medicine, Gunma 371-8511, Japan. khashi@med.gunma-u.ac.jp
FAU - Mori, Masatomo
AU  - Mori M
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110909
PL  - Japan
TA  - Endocr J
JT  - Endocrine journal
JID - 9313485
RN  - 0 (Liver X Receptors)
RN  - 0 (Orphan Nuclear Receptors)
RN  - 0 (Receptors, Thyroid Hormone)
SB  - IM
MH  - Animals
MH  - Humans
MH  - *Lipid Metabolism
MH  - Liver X Receptors
MH  - Orphan Nuclear Receptors/*metabolism
MH  - *Receptor Cross-Talk
MH  - Receptors, Thyroid Hormone/*metabolism
MH  - Signal Transduction
EDAT- 2011/09/13 06:00
MHDA- 2012/06/06 06:00
CRDT- 2011/09/13 06:00
PHST- 2011/09/13 06:00 [entrez]
PHST- 2011/09/13 06:00 [pubmed]
PHST- 2012/06/06 06:00 [medline]
AID - JST.JSTAGE/endocrj/EJ11-0114 [pii]
AID - 10.1507/endocrj.ej11-0114 [doi]
PST - ppublish
SO  - Endocr J. 2011;58(11):921-30. doi: 10.1507/endocrj.ej11-0114. Epub 2011 Sep 9.