PMID- 2191189
OWN - NLM
STAT- MEDLINE
DCOM- 19900713
LR  - 20190725
IS  - 0026-0495 (Print)
IS  - 0026-0495 (Linking)
VI  - 39
IP  - 6
DP  - 1990 Jun
TI  - Effects of intraperitoneal versus subcutaneous insulin administration on 
      lipoprotein metabolism in type I diabetes.
PG  - 598-604
AB  - In order to compare the effects of intraperitoneal (IP) versus subcutaneous (SC) 
      insulin delivery on plasma lipoproteins, lipoprotein cholesterol, triglycerides, 
      and very-low-density lipoprotein (VLDL) metabolism were compared in five type I 
      diabetic patients while they were receiving continuous IP insulin (CIPII) or 
      continuous subcutaneous insulin infusion (CSII). Each therapy regimen was of at 
      least 1 month duration, and patients were treated in random order. Mean daily 
      plasma insulin was lower on CIPII compared with CSII. CIPII was associated with 
      lower VLDL triglycerides and VLDL apolipoprotein (apo) B, and higher high-density 
      lipoprotein (HDL) and HDL3 cholesterol. The decreased VLDL on CIPII appeared to 
      be the result of both decreased production and increased clearance of VLDL apo B. 
      The results suggest that the more physiologic route of insulin therapy (CIPII) is 
      associated with lipoprotein profiles of lower atherogenic potential.
FAU - Ruotolo, G
AU  - Ruotolo G
AD  - National Institutes of Health, Phoenix, AZ.
FAU - Micossi, P
AU  - Micossi P
FAU - Galimberti, G
AU  - Galimberti G
FAU - Librenti, M C
AU  - Librenti MC
FAU - Petrella, G
AU  - Petrella G
FAU - Marcovina, S
AU  - Marcovina S
FAU - Pozza, G
AU  - Pozza G
FAU - Howard, B V
AU  - Howard BV
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Apolipoproteins B)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Insulin)
RN  - 0 (Lipoproteins)
RN  - 0 (Lipoproteins, VLDL)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Adult
MH  - Apolipoproteins B/blood
MH  - Cholesterol, LDL/blood
MH  - Diabetes Mellitus, Type 1/*blood/drug therapy
MH  - Female
MH  - Humans
MH  - Infusion Pumps
MH  - Injections, Intraperitoneal
MH  - Injections, Subcutaneous
MH  - Insulin/*administration & dosage/therapeutic use
MH  - Kinetics
MH  - Lipoproteins/*blood
MH  - Lipoproteins, VLDL/metabolism
MH  - Male
MH  - Middle Aged
MH  - Triglycerides/blood
EDAT- 1990/06/01 00:00
MHDA- 1990/06/01 00:01
CRDT- 1990/06/01 00:00
PHST- 1990/06/01 00:00 [pubmed]
PHST- 1990/06/01 00:01 [medline]
PHST- 1990/06/01 00:00 [entrez]
AID - 0026-0495(90)90025-8 [pii]
AID - 10.1016/0026-0495(90)90025-8 [doi]
PST - ppublish
SO  - Metabolism. 1990 Jun;39(6):598-604. doi: 10.1016/0026-0495(90)90025-8.