PMID- 21912845
OWN - NLM
STAT- MEDLINE
DCOM- 20120918
LR  - 20211020
IS  - 1573-2649 (Electronic)
IS  - 0962-9343 (Linking)
VI  - 21
IP  - 5
DP  - 2012 Jun
TI  - Ten-year quality of life outcomes among patients with schizophrenia and 
      schizoaffective disorders: I. Predictive value of disorder-related factors.
PG  - 837-47
LID - 10.1007/s11136-011-9988-2 [doi]
AB  - PURPOSE: To provide data on long-term health-related quality of life (HRQL) 
      outcomes among patients with schizophrenia (SZ) and schizoaffective (SA) 
      disorders and determine the predictive value of disorder-related factors. 
      METHODS: A total of 108 patients with SZ/SA were assessed during stabilization 
      phase and over 10 years with the Quality of Life Enjoyment and Life Satisfaction 
      Questionnaire (Q-LES-Q), Clinical Global Impression Scale, Positive and Negative 
      Syndromes Scale (PANSS), Distress Scale for Adverse Symptoms (DSAS), Talbieh 
      Brief Distress Inventory (TBDI), Brief Symptom Inventory-Somatization Scale 
      (BSI-S), and Global Assessment of Functioning Scale (GAF). Variability and 
      relationships between Q-LES-Q and disorder-related dimensions over time were 
      analyzed. RESULTS: There were no differences in Q-LES-Q dimensions between 
      patients with SZ and SA disorders. Poor outcomes were found among 76% of the 
      patients with SZ/SA disorders who remained dissatisfied (64%) or worsened (12%) 
      with their HRQL over time. However, 24% of patients reported improved quality of 
      life (16%), or remained satisfied (8%). Changes in TBDI, DSAS, BSI-S, PANSS, and 
      GAF measures accounted for 20-50% of the total variance in satisfaction changes 
      in Q-LES-Q domains across time. CONCLUSIONS: Long-term quality of life outcomes 
      are characterized by four different types that fit changes over time in emotional 
      distress, side effects, somatization, symptom dimensions, and general functioning 
      scores. Revealed predictors are factors that can be ameliorated and thereby 
      enhance satisfaction with quality of life over time.
FAU - Ritsner, Michael S
AU  - Ritsner MS
AD  - Department of Psychiatry, Rappaport Faculty of Medicine, Technion-Israel 
      Institute of Technology, Haifa, Israel. ritsner@sm.health.gov.il
FAU - Lisker, Alexander
AU  - Lisker A
FAU - Arbitman, Marina
AU  - Arbitman M
LA  - eng
PT  - Journal Article
DEP - 20110913
PL  - Netherlands
TA  - Qual Life Res
JT  - Quality of life research : an international journal of quality of life aspects of 
      treatment, care and rehabilitation
JID - 9210257
SB  - IM
MH  - Adaptation, Psychological
MH  - Adult
MH  - Analysis of Variance
MH  - Chi-Square Distribution
MH  - Female
MH  - Health Status Indicators
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Personal Satisfaction
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Psychometrics
MH  - Psychotic Disorders/drug therapy/*psychology
MH  - Quality of Life/*psychology
MH  - Schizophrenia/*drug therapy
MH  - *Schizophrenic Psychology
MH  - Severity of Illness Index
MH  - Statistics, Nonparametric
MH  - Stress, Psychological
MH  - Surveys and Questionnaires
MH  - Time Factors
MH  - *Treatment Outcome
MH  - Young Adult
EDAT- 2011/09/14 06:00
MHDA- 2012/09/19 06:00
CRDT- 2011/09/14 06:00
PHST- 2011/07/28 00:00 [accepted]
PHST- 2011/09/14 06:00 [entrez]
PHST- 2011/09/14 06:00 [pubmed]
PHST- 2012/09/19 06:00 [medline]
AID - 10.1007/s11136-011-9988-2 [doi]
PST - ppublish
SO  - Qual Life Res. 2012 Jun;21(5):837-47. doi: 10.1007/s11136-011-9988-2. Epub 2011 
      Sep 13.