PMID- 21914024
OWN - NLM
STAT- MEDLINE
DCOM- 20121009
LR  - 20120208
IS  - 1540-8167 (Electronic)
IS  - 1045-3873 (Linking)
VI  - 23
IP  - 2
DP  - 2012 Feb
TI  - Cardiac resynchronization therapy: do women benefit more than men?
PG  - 172-8
LID - 10.1111/j.1540-8167.2011.02168.x [doi]
AB  - INTRODUCTION: Women are underrepresented in cardiac resynchronization therapy 
      (CRT) trials. Whether there is a gender difference in the benefit derived from 
      CRT has not been well studied. METHODS: This study included 728 consecutive CRT 
      recipients at our institution who met guidelines for placement of a CRT device. 
      Clinical characteristics and echocardiographic parameters were collected at 
      baseline and after CRT; Kaplan-Meier survival analysis was performed using a 
      national death and location database. The effects and outcome of CRT were 
      compared between women and men. RESULTS: Of 728 patients, 166 were female 
      (22.8%). Female patients were younger than male patients (66.0 +/- 11.9 years vs 
      69.4 +/- 10.9 years; P < 0.001) and more often had nonischemic cardiomyopathy (68% 
      vs 36%; P < 0.001). Both female and male patients had significantly improved 
      clinical and echocardiographic parameters after CRT. The magnitude of improvement 
      was similar in women and men, except that improvement in New York Heart 
      Association (NYHA) class was greater in women than in men (-0.79 +/- 0.78 vs -0.56 
      +/- 0.85; P = 0.009). Although women were at lower risk of death than men after CRT 
      (hazard ratio, 0.51; 95% confidence interval, 0.35-0.75; P < 0.001, unadjusted), 
      multivariate analysis indicated gender was not, but age at CRT placement, 
      cardiomyopathy cause, NYHA class, and lead location were independent predictors 
      of survival. CONCLUSION: Female CRT recipients seem to achieve greater survival 
      benefit than male recipients. However, this benefit is majorly driven by 
      nonischemic cardiomyopathy and other clinical factors.
CI  - (c) 2011 Wiley Periodicals, Inc.
FAU - Xu, Yi-Zhou
AU  - Xu YZ
AD  - Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota 55905, 
      USA.
FAU - Friedman, Paul A
AU  - Friedman PA
FAU - Webster, Tracy
AU  - Webster T
FAU - Brooke, Kelly
AU  - Brooke K
FAU - Hodge, David O
AU  - Hodge DO
FAU - Wiste, Heather J
AU  - Wiste HJ
FAU - Hua, Wei
AU  - Hua W
FAU - Zhang, Shu
AU  - Zhang S
FAU - Hayes, David L
AU  - Hayes DL
FAU - Cha, Yong-Mei
AU  - Cha YM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110913
PL  - United States
TA  - J Cardiovasc Electrophysiol
JT  - Journal of cardiovascular electrophysiology
JID - 9010756
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cardiac Resynchronization Therapy/methods/*trends
MH  - Clinical Trials as Topic/trends
MH  - Cohort Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/*epidemiology/physiopathology/*therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Risk Factors
MH  - *Sex Characteristics
MH  - Treatment Outcome
EDAT- 2011/09/15 06:00
MHDA- 2012/10/10 06:00
CRDT- 2011/09/15 06:00
PHST- 2011/09/15 06:00 [entrez]
PHST- 2011/09/15 06:00 [pubmed]
PHST- 2012/10/10 06:00 [medline]
AID - 10.1111/j.1540-8167.2011.02168.x [doi]
PST - ppublish
SO  - J Cardiovasc Electrophysiol. 2012 Feb;23(2):172-8. doi: 
      10.1111/j.1540-8167.2011.02168.x. Epub 2011 Sep 13.