PMID- 21914086
OWN - NLM
STAT- MEDLINE
DCOM- 20120110
LR  - 20211203
IS  - 1365-2893 (Electronic)
IS  - 1352-0504 (Linking)
VI  - 18
IP  - 10
DP  - 2011 Oct
TI  - Ethnicity and route of HCV infection can influence the associations of HLA with 
      viral clearance in an ethnically heterogeneous population.
PG  - 692-9
LID - 10.1111/j.1365-2893.2010.01429.x [doi]
AB  - Approximately 20% of hepatitis C virus (HCV) infected individuals clear the 
      virus. Host factors that influence the course of HCV infection are still under 
      investigation, and the data on the association of human leukocyte antigen (HLA) 
      alleles and HCV clearance are scarce and controversial. The aims of this study 
      were to investigate whether HLA alleles are associated with clearance of HCV 
      infection in a highly admixed Brazilian population and whether these associations 
      could be influenced by ethnicity and route of infection. HLA-A, -B, -C, -DRB1 and 
      -DQB1 genotyping were performed in 135 HCV-infected Brazilian patients among 
      which 45 cleared HCV infection (cases) and 90 had persistent viral infection 
      (controls). Controls were matched by sex, ethnicity (withes and non-whites) and 
      route of infection (high infectious dose or low infectious dose). No significant 
      association was identified between HLA alleles and the outcome of HCV infection 
      when analyzing the sample as a single group. However, a new protective 
      association of HLA-DQB1*04 (P = 0.006; P(c) = 0.030) and a rarely described 
      association of HLA-DRB1*08 (P = 0.004; P(c) = 0.048) were found only among white 
      patients. The DRB1*11 allele, previously reported in homogeneous population, was 
      associated with HCV clearance (P = 0.020) only among patients with expected 
      high-dose exposure. These findings confirm the influence of ethnicity on the 
      associations of HLA with spontaneous viral clearance of HCV infection and 
      emphasize the possible influence of route of infection in this process.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - de Almeida, B S
AU  - de Almeida BS
AD  - Department of Gastroenterology, Rio de Janeiro State University, Rio de Janeiro, 
      Brazil. balmeidauff@hotmail.com
FAU - Silva, G M Fabricio
AU  - Silva GM
FAU - da Silva, P M
AU  - da Silva PM
FAU - Perez, R de Mello
AU  - Perez Rde M
FAU - Figueiredo, F A F
AU  - Figueiredo FA
FAU - Porto, L C
AU  - Porto LC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110408
PL  - England
TA  - J Viral Hepat
JT  - Journal of viral hepatitis
JID - 9435672
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brazil
MH  - *Disease Resistance
MH  - Ethnicity
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA Antigens/*genetics/*immunology
MH  - Hepatitis C/*genetics/*immunology/transmission
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 2011/09/15 06:00
MHDA- 2012/01/11 06:00
CRDT- 2011/09/15 06:00
PHST- 2011/09/15 06:00 [entrez]
PHST- 2011/09/15 06:00 [pubmed]
PHST- 2012/01/11 06:00 [medline]
AID - 10.1111/j.1365-2893.2010.01429.x [doi]
PST - ppublish
SO  - J Viral Hepat. 2011 Oct;18(10):692-9. doi: 10.1111/j.1365-2893.2010.01429.x. Epub 
      2011 Apr 8.