PMID- 21917120
OWN - NLM
STAT- MEDLINE
DCOM- 20120430
LR  - 20211020
IS  - 1742-7843 (Electronic)
IS  - 1742-7835 (Print)
IS  - 1742-7835 (Linking)
VI  - 110
IP  - 1
DP  - 2012 Jan
TI  - Calcium and electrical signalling along endothelium of the resistance 
      vasculature.
PG  - 80-6
LID - 10.1111/j.1742-7843.2011.00798.x [doi]
AB  - This MiniReview is focused on the nature of intercellular signalling along the 
      endothelium that helps to co-ordinate blood flow control in vascular resistance 
      networks. Vasodilation initiated by contracting skeletal muscle ascends from 
      arterioles within the tissue to encompass resistance arteries upstream and 
      thereby increase blood flow during exercise. In resistance vessels, acetylcholine 
      microiontophoresis or intracellular current injection initiates hyperpolarization 
      that conducts through gap junction channels (GJCs) along the vessel wall 
      resulting in conducted vasodilation (CVD). Both ascending vasodilation and CVD 
      are eliminated with endothelial cell (EC) disruption, pointing to common 
      signalling events and mutual dependence upon EC integrity. As demonstrated by 
      electrical coupling and dye transfer during intracellular recording, their 
      longitudinal orientation and robust expression of GJCs enable ECs to play a 
      predominant role in CVD. Once conduction is initiated, a major interest centres 
      on whether CVD is purely passive or involves additional 'active' signalling 
      events. Here, we discuss components for Ca(2)(+) and electrical signalling with an 
      emphasis on intercellular coupling through endothelial GJCs. We stress the 
      importance of understanding relationships between intracellular Ca(2)(+) dynamics, EC 
      hyperpolarization and CVD while integrating findings from isolated ECs into more 
      complex interactions in vivo. Whereas endothelial dysfunction accompanies 
      cardiovascular disease and the components of intra- and inter-cellular signalling 
      are increasingly well defined, little is known of how Ca(2)(+) signalling and 
      electrical conduction along microvascular endothelium are altered in diseased 
      states. Thus, greater insight into how these relationships are governed and 
      interact is a key goal for continued research efforts.
CI  - (c) 2011 The Authors. Basic & Clinical Pharmacology & Toxicology (c) 2011 Nordic 
      Pharmacological Society.
FAU - Socha, Matthew J
AU  - Socha MJ
AD  - Department of Medical Pharmacology and Physiology, University of Missouri, 
      Columbia, MO 65212, USA.
FAU - Behringer, Erik J
AU  - Behringer EJ
FAU - Segal, Steven S
AU  - Segal SS
LA  - eng
GR  - R01 HL086483/HL/NHLBI NIH HHS/United States
GR  - R37 HL041026-19/HL/NHLBI NIH HHS/United States
GR  - F32-HL110701/HL/NHLBI NIH HHS/United States
GR  - R01 HL086483-04/HL/NHLBI NIH HHS/United States
GR  - R37 HL041026-18/HL/NHLBI NIH HHS/United States
GR  - R37-HL041026/HL/NHLBI NIH HHS/United States
GR  - R01 HL086483-03/HL/NHLBI NIH HHS/United States
GR  - F32-HL107050/HL/NHLBI NIH HHS/United States
GR  - R37 HL041026/HL/NHLBI NIH HHS/United States
GR  - F32 HL110701/HL/NHLBI NIH HHS/United States
GR  - R01-HL086483/HL/NHLBI NIH HHS/United States
GR  - F32 HL107050/HL/NHLBI NIH HHS/United States
GR  - T32-AR048523/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20111020
PL  - England
TA  - Basic Clin Pharmacol Toxicol
JT  - Basic & clinical pharmacology & toxicology
JID - 101208422
SB  - IM
MH  - Animals
MH  - Blood Vessels/physiology/physiopathology
MH  - *Calcium Signaling
MH  - Cardiovascular Diseases/metabolism/physiopathology
MH  - Endothelium, Vascular/*physiology/physiopathology
MH  - Humans
MH  - *Membrane Potentials
MH  - Microcirculation
MH  - Microvessels/*physiology/physiopathology
MH  - Regional Blood Flow
MH  - *Vascular Resistance
MH  - Vasoconstriction
MH  - Vasodilation
PMC - PMC3271116
MID - NIHMS324494
EDAT- 2011/09/16 06:00
MHDA- 2012/05/01 06:00
PMCR- 2013/01/01
CRDT- 2011/09/16 06:00
PHST- 2011/09/16 06:00 [entrez]
PHST- 2011/09/16 06:00 [pubmed]
PHST- 2012/05/01 06:00 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - 10.1111/j.1742-7843.2011.00798.x [doi]
PST - ppublish
SO  - Basic Clin Pharmacol Toxicol. 2012 Jan;110(1):80-6. doi: 
      10.1111/j.1742-7843.2011.00798.x. Epub 2011 Oct 20.