PMID- 21917484
OWN - NLM
STAT- MEDLINE
DCOM- 20120306
LR  - 20181201
IS  - 1532-2688 (Electronic)
IS  - 1059-1311 (Linking)
VI  - 20
IP  - 10
DP  - 2011 Dec
TI  - Early clinical experience with lacosamide as adjunctive therapy in patients with 
      refractory focal epilepsy and nocturnal seizures.
PG  - 801-4
LID - 10.1016/j.seizure.2011.08.005 [doi]
AB  - This retrospective study reports the early experience with lacosamide (LCM) as 
      adjunctive therapy in Spanish patients with refractory focal epilepsy. Sixty 
      patients (mean age 38.3 years, 54% women, mean epilepsy duration 27.2 years, mean 
      seizure rate 9.7/month, and 28% with mainly nocturnal seizures) taking >/=2 
      antiepileptic drugs (mean 2.2) were included. LCM maintenance doses were 200, 
      300, 400, and 500mg/day in 31, 16, 10, and 3 patients, respectively. Patients 
      were followed up for 13-24 months. Twenty-eight patients (47%) reported a >/=50% 
      reduction in seizure frequency. A >/=50% reduction in seizure frequency was 
      reported by 65% and 40% of patients in the nocturnal seizure and diurnal seizure 
      subgroups, respectively (p>0.05). Of the 28 responders, 2 achieved stable periods 
      of seizure freedom of 6 and 11 months after starting LCM. Twenty patients (33%) 
      reported drug-related adverse events (AEs); the most common was dizziness (16 
      patients). LCM was withdrawn in 8 patients (13%). There were no serious AEs. 
      These results support the efficacy and safety of adjunctive LCM in patients with 
      partial-onset seizures.
CI  - 2011 British Epilepsy Association. Published by Elsevier Ltd. All rights 
      reserved.
FAU - Garcia-Morales, Irene
AU  - Garcia-Morales I
AD  - Epilepsy Unit, Department of Neurology, Hospital Universitario Clinico San 
      Carlos, Madrid, Spain. ingmorales@hotmail.com
FAU - Delgado, Rafael Toledano
AU  - Delgado RT
FAU - Falip, Merce
AU  - Falip M
FAU - Campos, Dulce
AU  - Campos D
FAU - Garcia, Maria Eugenia
AU  - Garcia ME
FAU - Gil-Nagel, Antonio
AU  - Gil-Nagel A
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20110913
PL  - England
TA  - Seizure
JT  - Seizure
JID - 9306979
RN  - 0 (Acetamides)
RN  - 0 (Anticonvulsants)
RN  - 563KS2PQY5 (Lacosamide)
SB  - IM
MH  - Acetamides/*therapeutic use
MH  - Adult
MH  - Aged
MH  - Anticonvulsants/*therapeutic use
MH  - Drug Therapy, Combination
MH  - Epilepsies, Partial/complications/*drug therapy
MH  - Female
MH  - Humans
MH  - Lacosamide
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Seizures/etiology/prevention & control
MH  - Young Adult
EDAT- 2011/09/16 06:00
MHDA- 2012/03/07 06:00
CRDT- 2011/09/16 06:00
PHST- 2011/05/17 00:00 [received]
PHST- 2011/08/10 00:00 [revised]
PHST- 2011/08/11 00:00 [accepted]
PHST- 2011/09/16 06:00 [entrez]
PHST- 2011/09/16 06:00 [pubmed]
PHST- 2012/03/07 06:00 [medline]
AID - S1059-1311(11)00210-X [pii]
AID - 10.1016/j.seizure.2011.08.005 [doi]
PST - ppublish
SO  - Seizure. 2011 Dec;20(10):801-4. doi: 10.1016/j.seizure.2011.08.005. Epub 2011 Sep 
      13.