PMID- 21918107
OWN - NLM
STAT- MEDLINE
DCOM- 20120413
LR  - 20220310
IS  - 1946-6242 (Electronic)
IS  - 1946-6234 (Print)
IS  - 1946-6234 (Linking)
VI  - 3
IP  - 100
DP  - 2011 Sep 14
TI  - Donor myocardial infarction impairs the therapeutic potential of bone marrow 
      cells by an interleukin-1-mediated inflammatory response.
PG  - 100ra90
LID - 10.1126/scitranslmed.3002814 [doi]
AB  - Delivery of bone marrow cells (BMCs) to the heart has substantially improved 
      cardiac function in most rodent models of myocardial infarction (MI), but 
      clinical trials of BMC therapy have led to only modest improvements. Rodent 
      models typically involve intramyocardial injection of BMCs from distinct donor 
      individuals who are healthy. In contrast, autologous BMCs from individuals after 
      MI are used for clinical trials. Using BMCs from donor mice after MI, we 
      discovered that recent MI impaired BMC therapeutic efficacy. MI led to myocardial 
      inflammation and an increased inflammatory state in the bone marrow, changing the 
      BMC composition and reducing their efficacy. Injection of a general 
      anti-inflammatory drug or a specific interleukin-1 inhibitor to donor mice after 
      MI prevented this impairment. Our findings offer an explanation of why human 
      trials have not matched the success of rodent experiments and suggest potential 
      strategies to improve the success of clinical autologous BMC therapy.
FAU - Wang, Xiaoyin
AU  - Wang X
AD  - Cardiovascular Research Institute, University of California, San Francisco, San 
      Francisco, CA 94143, USA.
FAU - Takagawa, Junya
AU  - Takagawa J
FAU - Lam, Viola C
AU  - Lam VC
FAU - Haddad, Daniel J
AU  - Haddad DJ
FAU - Tobler, Diana L
AU  - Tobler DL
FAU - Mok, Pamela Y
AU  - Mok PY
FAU - Zhang, Yan
AU  - Zhang Y
FAU - Clifford, Brian T
AU  - Clifford BT
FAU - Pinnamaneni, Kranthi
AU  - Pinnamaneni K
FAU - Saini, Shereen A
AU  - Saini SA
FAU - Su, Robert
AU  - Su R
FAU - Bartel, Maya J
AU  - Bartel MJ
FAU - Sievers, Richard E
AU  - Sievers RE
FAU - Carbone, Larry
AU  - Carbone L
FAU - Kogan, Scott
AU  - Kogan S
FAU - Yeghiazarians, Yerem
AU  - Yeghiazarians Y
FAU - Hermiston, Michelle
AU  - Hermiston M
FAU - Springer, Matthew L
AU  - Springer ML
LA  - eng
GR  - R01 HL086917/HL/NHLBI NIH HHS/United States
GR  - R03 EB005802/EB/NIBIB NIH HHS/United States
GR  - R21 HL097129/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Sci Transl Med
JT  - Science translational medicine
JID - 101505086
RN  - 0 (Interleukin-1)
SB  - IM
MH  - Animals
MH  - Bone Marrow Transplantation/*methods
MH  - Echocardiography
MH  - Flow Cytometry
MH  - Interleukin-1/*metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Myocardial Infarction/*immunology/pathology/*therapy
MH  - *Tissue Donors
PMC - PMC3350804
MID - NIHMS375523
EDAT- 2011/09/16 06:00
MHDA- 2012/04/14 06:00
PMCR- 2012/05/13
CRDT- 2011/09/16 06:00
PHST- 2011/09/16 06:00 [entrez]
PHST- 2011/09/16 06:00 [pubmed]
PHST- 2012/04/14 06:00 [medline]
PHST- 2012/05/13 00:00 [pmc-release]
AID - 3/100/100ra90 [pii]
AID - 10.1126/scitranslmed.3002814 [doi]
PST - ppublish
SO  - Sci Transl Med. 2011 Sep 14;3(100):100ra90. doi: 10.1126/scitranslmed.3002814.