PMID- 2191854
OWN - NLM
STAT- MEDLINE
DCOM- 19900723
LR  - 20181113
IS  - 0012-6667 (Print)
IS  - 0012-6667 (Linking)
VI  - 39 Suppl 4
DP  - 1990
TI  - M-mode echocardiography in patients with severe congestive heart failure. A 
      subgroup analysis in the Cooperative North Scandinavian Enalapril Survival Study 
      (CONSENSUS).
PG  - 43-8; discussion 53-4
AB  - In the CONSENSUS study, M-mode echocardiography was used as an optional 
      examination. All patients were in severe congestive heart failure [New York Heart 
      Association (NYHA) functional class IV], and all patients had radiologically 
      marked increased heart size. Of 253 patients, M-mode echocardiography was done at 
      baseline in 105 patients. M-mode echocardiographic recordings from 70 patients 
      were received, and of these, only 54 patients (77%) had recordings of acceptable 
      quality for evaluation. At follow-up, M-mode echocardiography was done after 6 
      weeks, 6 months and 12 months. However, because of the high mortality and the 
      premature cessation of the study, only a limited number of patients had M-mode 
      echocardiographic registrations after greater than 6 weeks. All M-mode 
      echocardiographic registrations were analysed by 2 investigators independently. 
      Systolic time interval (STI) decreased from 0.58 to 0.48 (p less than 0.05) in 
      the enalapril group after 6 weeks. In the placebo group, a small increase in STI 
      from 0.54 to 0.56 (not significant) was seen after 6 weeks. The decrease in STI 
      in the enalapril group was secondary to an increase in left ventricular ejection 
      time. No significant change was seen in left ventricular and left atrial 
      diameters at follow-up: this finding can be explained by a type 2 error. These 
      findings indicate an increased STI in the enalapril-treated group, which could 
      explain why enalapril treatment reduced mortality in the CONSENSUS study.
FAU - Eriksson, S V
AU  - Eriksson SV
AD  - Department of Medicine, Danderyd Hospital, Sweden.
FAU - Offstad, J
AU  - Offstad J
FAU - Kjekshus, J
AU  - Kjekshus J
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - New Zealand
TA  - Drugs
JT  - Drugs
JID - 7600076
SB  - IM
MH  - Aged
MH  - Double-Blind Method
MH  - *Echocardiography
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/*diagnosis/mortality
MH  - Humans
MH  - Male
MH  - Multicenter Studies as Topic
MH  - Randomized Controlled Trials as Topic
MH  - Scandinavian and Nordic Countries
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
AID - 10.2165/00003495-199000394-00009 [doi]
PST - ppublish
SO  - Drugs. 1990;39 Suppl 4:43-8; discussion 53-4. doi: 
      10.2165/00003495-199000394-00009.