PMID- 21919963
OWN - NLM
STAT- MEDLINE
DCOM- 20120809
LR  - 20120417
IS  - 1399-0012 (Electronic)
IS  - 0902-0063 (Linking)
VI  - 26
IP  - 2
DP  - 2012 Mar-Apr
TI  - The effect of HLA disparity on clinical outcome after HLA-haploidentical blood 
      and marrow transplantation.
PG  - 284-91
LID - 10.1111/j.1399-0012.2011.01499.x [doi]
AB  - The relative importance of various human leukocyte antigen (HLA) loci has not 
      been established for unmanipulated HLA-mismatched/haploidentical transplantation. 
      To address this question, we analyzed the impact of HLA-A, HLA-B, HLA-DRB1, 
      HLA-DRB3, HLA-DRB4, and HLA-DRB5 on the outcome of HLA-haploidentical 
      transplantation. Four hundred and eighty-one donor-recipient pairs were fully 
      typed before transplantation. In univariate analysis, HLA-B mismatch not only 
      demonstrated significant adverse effects on acute graft-versus-host disease 
      (GVHD) and transplant-related mortality but also was associated with reduced 
      overall survival and leukemia-free survival (LFS). In multivariate analysis, 
      HLA-B mismatch remained the independent risk factor for acute GVHD and 
      transplant-related mortality. The high risk of disease and the female donor were 
      found to be significant factors for reduced overall survival and LFS. 
      Furthermore, multiple mismatch of the HLA locus was found to have no synergistic 
      adverse effect on outcomes. Our results suggest that prospective matching of 
      patients and donors for HLA-B antigen in the unshared HLA haplotype is warranted 
      for HLA-mismatched/haploidentical transplantation.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Huo, Ming-Rui
AU  - Huo MR
AD  - Peking University People's Hospital, Peking Peking University Institute of 
      Hematology, Beijing, China.
FAU - Xu, Lan-Ping
AU  - Xu LP
FAU - Li, D
AU  - Li D
FAU - Liu, Dai-Hong
AU  - Liu DH
FAU - Liu, Kai-Yan
AU  - Liu KY
FAU - Chen, Huan
AU  - Chen H
FAU - Han, Wei
AU  - Han W
FAU - Chen, Yu-Hong
AU  - Chen YH
FAU - Wang, Y
AU  - Wang Y
FAU - Wang, Jing-Zhi
AU  - Wang JZ
FAU - Zhang, Xiao-Hui
AU  - Zhang XH
FAU - Zhao, Xiang-Yu
AU  - Zhao XY
FAU - Huang, Xiao-Jun
AU  - Huang XJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110915
PL  - Denmark
TA  - Clin Transplant
JT  - Clinical transplantation
JID - 8710240
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - *Blood Transfusion
MH  - Bone Marrow Transplantation/adverse effects/*immunology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Graft vs Host Disease/etiology
MH  - HLA Antigens/*analysis
MH  - *Haplotypes
MH  - Hematologic Neoplasms/immunology/therapy
MH  - *Histocompatibility
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Young Adult
EDAT- 2011/09/17 06:00
MHDA- 2012/08/10 06:00
CRDT- 2011/09/17 06:00
PHST- 2011/09/17 06:00 [entrez]
PHST- 2011/09/17 06:00 [pubmed]
PHST- 2012/08/10 06:00 [medline]
AID - 10.1111/j.1399-0012.2011.01499.x [doi]
PST - ppublish
SO  - Clin Transplant. 2012 Mar-Apr;26(2):284-91. doi: 
      10.1111/j.1399-0012.2011.01499.x. Epub 2011 Sep 15.