PMID- 21920769
OWN - NLM
STAT- MEDLINE
DCOM- 20120315
LR  - 20111121
IS  - 1096-0023 (Electronic)
IS  - 1043-4666 (Linking)
VI  - 56
IP  - 3
DP  - 2011 Dec
TI  - Apheresis-inducible cytokine pattern change in severe, genetic dyslipidemias.
PG  - 835-41
LID - 10.1016/j.cyto.2011.08.024 [doi]
AB  - OBJECTIVE: The effects of direct adsorption of lipids LDL-apheresis (DALILDL-a) 
      on plasma cytokines in two Homozygous and heterozygous familial 
      hypercholesterolemic (HozFH, HtzFH) and in four HyperLp(a)lipoproteinemic 
      [HyperLp(a)] patients, were evaluated. METHODS: Plasma, macrophage inflammatory 
      proteins 1alpha (MIP-1alpha), macrophage inflammatory proteins 1beta (MIP-1beta), monocyte 
      chemoattractant protein-1 (MCP-1), RANTES (Regulated upon Activation, Normal 
      T-cell Expressed, and Secreted), granulocyte-colony stimulating factor (GCSF), 
      granulocyte macrophage-colony stimulating factor (GM-CSF), interleukin-1alpha 
      (IL-1alpha), interleukin-1beta (IL-1beta), interleukin-2 (IL-2), interleukin-6 (IL-6), 
      interferon-gamma (IFN-gamma), concentrations, were measured before and after LDL-a on 
      three consecutive sessions for each patient. RESULTS: MIP-1alpha was significantly 
      reduced (P=0.05), while MIP-1beta was significantly increased (P=0.05). Plasma MCP-1 
      was reduced, although not significantly, while RANTES was significantly increased 
      (P=0.05). GCSF and GM-CSF were both significantly reduced (GM-CSF: P=0.05, GCSF: 
      P=0.05, respectively). IL-1alpha level was significantly reduced (P=0.001). IL-1beta, 
      IL-6, and IFN-gamma levels were significantly reduced in plasma after apheresis 
      (IL-1beta: P=0.001, IL-6: T1 P=0.001; T2 P=0.05, respectively, IFN-gamma: P=0.001). IL-2 
      level in plasma was significantly reduced at T0, and T2, (P=0.001). However, IL-2 
      level showed a statistically significant increase at T1 (P=0.001). A significant 
      correlation between IL-1alpha and IFN-gamma was found: r=0.882 (P=0.001). CONCLUSIONS: In 
      this study LDL-a induced profound changes in several circulating cytokines and 
      promoted anti-inflammatory and anti-atherogenic cytokine profile in plasma of 
      patients with severe dyslipidemia, with pre-existing angiographically 
      demonstrated Coronary heart disease (CHD), and aortic valvular disease (#=1) 
      (AVD).
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Stefanutti, Claudia
AU  - Stefanutti C
AD  - Extracorporeal Therapeutic Techniques Unit-Immunohematology and Transfusion 
      Medicine, Department of Molecular Medicine, University of Rome La Sapienza, 
      Umberto I Hospital, Rome, Italy. cstefanutti@alice.it
FAU - Vivenzio, Antonio
AU  - Vivenzio A
FAU - Ferraro, Pietro Manuel
AU  - Ferraro PM
FAU - Morozzi, Claudia
AU  - Morozzi C
FAU - Belotherkovsky, Dany
AU  - Belotherkovsky D
LA  - eng
PT  - Journal Article
DEP - 20110914
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (Cytokines)
SB  - IM
MH  - Adult
MH  - *Blood Component Removal
MH  - Cytokines/*blood
MH  - Demography
MH  - Dyslipidemias/*blood/*genetics/immunology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Sample Size
EDAT- 2011/09/17 06:00
MHDA- 2012/03/16 06:00
CRDT- 2011/09/17 06:00
PHST- 2011/05/10 00:00 [received]
PHST- 2011/08/06 00:00 [revised]
PHST- 2011/08/13 00:00 [accepted]
PHST- 2011/09/17 06:00 [entrez]
PHST- 2011/09/17 06:00 [pubmed]
PHST- 2012/03/16 06:00 [medline]
AID - S1043-4666(11)00703-4 [pii]
AID - 10.1016/j.cyto.2011.08.024 [doi]
PST - ppublish
SO  - Cytokine. 2011 Dec;56(3):835-41. doi: 10.1016/j.cyto.2011.08.024. Epub 2011 Sep 
      14.