PMID- 21921049
OWN - NLM
STAT- MEDLINE
DCOM- 20120103
LR  - 20210206
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Linking)
VI  - 118
IP  - 19
DP  - 2011 Nov 10
TI  - Multiple HLA class I and II associations in classical Hodgkin lymphoma and EBV 
      status defined subgroups.
PG  - 5211-7
LID - 10.1182/blood-2011-04-342998 [doi]
AB  - The pathogenesis of classical Hodgkin lymphoma (cHL) involves environmental and 
      genetic factors. To explore the role of the human leukocyte antigen (HLA) genes, 
      we performed a case-control genotyping study in 338 Dutch cHL patients and more 
      than 5000 controls using a PCR-based sequence-specific oligonucleotide probe 
      hybridization approach. HLA-A68 and HLA-DR11 (5) were significantly increased in 
      the cHL patient population compared with the controls. Three class II 
      associations were observed in the EBV(-) cHL population with an increase of 
      HLA-DR15 (2) and a decrease of HLA-DR4 and HLA-DR7. Allele frequencies of HLA-A1, 
      HLA-B37, and HLA-DR10 were significantly increased in the EBV(+) cHL population; 
      these alleles are in strong linkage disequilibrium and form a common haplotype in 
      whites. The allele frequency of HLA-A2 was significantly decreased in the EBV(+) 
      cHL population. Sequence-specific oligonucleotide probe analysis revealed 
      significant differences between EBV(+) and EBV(-) cHL patients for 19 probes that 
      discriminate between HLA-A*01 and HLA-A*02. In conclusion, the HLA-A1 and HLA-A2 
      antigens and not specific single nucleotide variants shared by multiple alleles 
      are responsible for the association with EBV(+) cHL. Furthermore, several new 
      protective and predisposing HLA class I and II associations for the EBV(+), the 
      EBV(-), and the entire cHL population were identified.
FAU - Huang, Xin
AU  - Huang X
AD  - Department of Pathology and Medical Biology, University Medical Center Groningen, 
      University of Groningen, The Netherlands.
FAU - Kushekhar, Kushi
AU  - Kushekhar K
FAU - Nolte, Ilja
AU  - Nolte I
FAU - Kooistra, Wierd
AU  - Kooistra W
FAU - Visser, Lydia
AU  - Visser L
FAU - Bouwman, Ilby
AU  - Bouwman I
FAU - Kouprie, Niels
AU  - Kouprie N
FAU - Veenstra, Rianne
AU  - Veenstra R
FAU - van Imhoff, Gustaaf
AU  - van Imhoff G
FAU - Olver, Bianca
AU  - Olver B
FAU - Houlston, Richard S
AU  - Houlston RS
FAU - Poppema, Sibrand
AU  - Poppema S
FAU - Diepstra, Arjan
AU  - Diepstra A
FAU - Hepkema, Bouke
AU  - Hepkema B
FAU - van den Berg, Anke
AU  - van den Berg A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Retracted Publication
DEP - 20110914
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
SB  - IM
RIN - Blood. 2012 Apr 5;119(14):3370. PMID: 22267602
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Epstein-Barr Virus Infections/genetics/immunology
MH  - Female
MH  - Gene Frequency
MH  - *Genes, MHC Class I
MH  - *Genes, MHC Class II
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Herpesvirus 4, Human/isolation & purification/pathogenicity
MH  - Hodgkin Disease/classification/*genetics/*immunology/virology
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Male
MH  - Middle Aged
MH  - Netherlands
MH  - Young Adult
EDAT- 2011/09/17 06:00
MHDA- 2012/01/04 06:00
CRDT- 2011/09/17 06:00
PHST- 2011/09/17 06:00 [entrez]
PHST- 2011/09/17 06:00 [pubmed]
PHST- 2012/01/04 06:00 [medline]
AID - S0006-4971(20)40371-4 [pii]
AID - 10.1182/blood-2011-04-342998 [doi]
PST - ppublish
SO  - Blood. 2011 Nov 10;118(19):5211-7. doi: 10.1182/blood-2011-04-342998. Epub 2011 
      Sep 14.