PMID- 21921211
OWN - NLM
STAT- MEDLINE
DCOM- 20120118
LR  - 20211020
IS  - 1549-5485 (Electronic)
IS  - 1072-0502 (Print)
IS  - 1072-0502 (Linking)
VI  - 18
IP  - 10
DP  - 2011 Oct
TI  - Dorsal and ventral striatal protein synthesis inhibition affect reinforcer 
      valuation but not the consolidation of instrumental learning.
PG  - 617-24
LID - 10.1101/lm.2269911 [doi]
AB  - The evidence for a role of the striatum in the acquisition of uncued instrumental 
      responding is ambiguous. It has been shown that post-session infusions of 
      anisomycin into the core of the nucleus accumbens (NAcc) impaired instrumental 
      acquisition, but pre-training lesions of the NAcc suggest that it is not 
      necessary. Recently, we demonstrated that the infusion of anisomycin into the 
      anterior cingulate cortex impaired instrumental acquisition indirectly through a 
      taste aversion. Thus, we hypothesized that post-session anisomycin infusions into 
      the NAcc affected instrumental acquisition through an effect on reinforcer 
      valuation. For the dorsal striatum, both post-session infusions of anisomycin and 
      pre-training lesion studies suggest that neither the dorsolateral nor the 
      dorsomedial striatum is necessary for the acquisition of instrumental responding. 
      However, it has not been attempted to block plasticity in both regions 
      concurrently, and we hypothesized that both regions independently contribute to 
      acquisition through goal-directed and habitual learning. In the current 
      experiments, we first replicated the effect of unprotected post-session 
      anisomycin infusions into the NAcc on instrumental acquisition. Subsequently, we 
      investigated the effect of protein synthesis inhibition in the NAcc and 
      dorsomedial and dorsolateral striatum concurrently on instrumental acquisition, 
      critically controlling for effects on reinforcer valuation. The anisomycin 
      infusions induced an aversive state, but did not affect instrumental acquisition.
FAU - Jonkman, Sietse
AU  - Jonkman S
AD  - Behavioural and Clinical Neuroscience Institute, University of Cambridge, 
      Cambridge, United Kingdom. sj306@cam.ac.uk
FAU - Everitt, Barry J
AU  - Everitt BJ
LA  - eng
GR  - G0001354/MRC_/Medical Research Council/United Kingdom
GR  - G0600196/MRC_/Medical Research Council/United Kingdom
GR  - G1002231/MRC_/Medical Research Council/United Kingdom
GR  - 9536855/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110915
PL  - United States
TA  - Learn Mem
JT  - Learning & memory (Cold Spring Harbor, N.Y.)
JID - 9435678
RN  - 0 (Polysaccharides)
RN  - 0 (Protein Synthesis Inhibitors)
RN  - 6C74YM2NGI (Anisomycin)
RN  - 7CVR7L4A2D (maltodextrin)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Anisomycin/pharmacology
MH  - Conditioning, Operant/drug effects/*physiology
MH  - Corpus Striatum/drug effects/*metabolism
MH  - Male
MH  - Nucleus Accumbens/drug effects
MH  - Polysaccharides/administration & dosage
MH  - Protein Synthesis Inhibitors/pharmacology
MH  - Rats
MH  - *Reinforcement, Psychology
MH  - Time Factors
PMC - PMC3187930
EDAT- 2011/09/17 06:00
MHDA- 2012/01/19 06:00
PMCR- 2012/10/01
CRDT- 2011/09/17 06:00
PHST- 2011/09/17 06:00 [entrez]
PHST- 2011/09/17 06:00 [pubmed]
PHST- 2012/01/19 06:00 [medline]
PHST- 2012/10/01 00:00 [pmc-release]
AID - 18/10/617 [pii]
AID - JonkmanLM22699 [pii]
AID - 10.1101/lm.2269911 [doi]
PST - epublish
SO  - Learn Mem. 2011 Sep 15;18(10):617-24. doi: 10.1101/lm.2269911. Print 2011 Oct.