PMID- 21921366
OWN - NLM
STAT- MEDLINE
DCOM- 20120131
LR  - 20190606
IS  - 1349-7235 (Electronic)
IS  - 0918-2918 (Linking)
VI  - 50
IP  - 18
DP  - 2011
TI  - Selective contribution of waist circumference reduction on the improvement of 
      sleep-disordered breathing in patients hospitalized with type 2 diabetes 
      mellitus.
PG  - 1895-903
AB  - OBJECTIVE: Sleep-disordered breathing (SDB) is a potential risk factor for 
      cardiac sudden death. Recent studies have reported that patients with type 2 
      diabetes mellitus (T2DM) frequently suffer from SDB. Although the roles of 
      hyperglycemia, disturbances of the autonomic nervous system and obesity have been 
      postulated, the factors related to SDB in T2DM, especially those related to 
      improvement of SDB remain unknown. We investigated the significance of waist 
      circumference (WC), representing excess visceral fat, body mass index (BMI), 
      glycemic control and other clinical parameters on SDB in T2DM. METHODS AND 
      SUBJECTS: Forty inpatients received treatment for T2DM. Overnight 
      cardiorespiratory monitoring and laboratory tests were conducted before and after 
      treatment of T2DM. RESULTS: The apnea-hypopnea index (AHI) at admission 
      correlated positively with BMI, neck circumference, WC, and systolic and 
      diastolic blood pressures, but not with Log 1,5-anhydro-D-glucitol (1,5-AG) and 
      presence or absence of diabetic neuropathy. Stepwise multiple regression analysis 
      identified BMI and WC as significant determinants of AHI. After 2 or 3 weeks of 
      glucose-lowering therapy, hyperglycemia was controlled and significant reductions 
      in AHI, BMI, WC, 1,5-AG, leptin, high-sensitivity C-reactive protein (hs-CRP), 
      and an oxidative stress marker, thiobarbituric acid reactive substances (TBARS) 
      were observed. The fall in AHI correlated significantly with changes in WC 
      independent of BMI, 1,5-AG, leptin, hs-CRP, and TBARS. CONCLUSION: Our results 
      demonstrated that reduction of WC correlated with improvement in SDB independent 
      of glycemic control in T2DM, and that abdominal obesity might be a target for the 
      treatment of SDB and prevention of potential cardiovascular diseases in T2DM.
FAU - Kashine, Susumu
AU  - Kashine S
AD  - Department of Metabolic Medicine, Osaka University, Japan.
FAU - Kishida, Ken
AU  - Kishida K
FAU - Funahashi, Tohru
AU  - Funahashi T
FAU - Yasuda, Tetsuyuki
AU  - Yasuda T
FAU - Okita, Kohei
AU  - Okita K
FAU - Matsuzawa, Yuji
AU  - Matsuzawa Y
FAU - Shimomura, Iichiro
AU  - Shimomura I
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110915
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood Glucose/metabolism
MH  - Body Mass Index
MH  - Cardiovascular Diseases/epidemiology/prevention & control
MH  - Diabetes Mellitus, Type 2/blood/complications/*physiopathology
MH  - Female
MH  - Humans
MH  - *Inpatients
MH  - Male
MH  - Middle Aged
MH  - Polysomnography
MH  - Risk Factors
MH  - Sleep Apnea Syndromes/blood/complications/*physiopathology
MH  - Treatment Outcome
MH  - Waist Circumference/*physiology
MH  - Weight Loss/*physiology
EDAT- 2011/09/17 06:00
MHDA- 2012/02/01 06:00
CRDT- 2011/09/17 06:00
PHST- 2011/09/17 06:00 [entrez]
PHST- 2011/09/17 06:00 [pubmed]
PHST- 2012/02/01 06:00 [medline]
AID - JST.JSTAGE/internalmedicine/50.5669 [pii]
AID - 10.2169/internalmedicine.50.5669 [doi]
PST - ppublish
SO  - Intern Med. 2011;50(18):1895-903. doi: 10.2169/internalmedicine.50.5669. Epub 
      2011 Sep 15.