PMID- 21922263
OWN - NLM
STAT- MEDLINE
DCOM- 20130501
LR  - 20211020
IS  - 1439-6327 (Electronic)
IS  - 1439-6319 (Linking)
VI  - 112
IP  - 5
DP  - 2012 May
TI  - The effects of carbohydrate ingestion during endurance running on post-exercise 
      inflammation and hepcidin levels.
PG  - 1889-98
LID - 10.1007/s00421-011-2156-0 [doi]
AB  - The effect of carbohydrate (CHO) consumption during prolonged endurance running 
      on post-exercise inflammation and hepcidin levels was investigated. Eleven 
      well-trained male endurance athletes completed a graded exercise test, followed 
      by two experimental running trials in a randomized order. The two experimental 
      trials consisted of a 90 min run at 75% of the peak oxygen uptake velocity 
      (vVO(2peak)), while consuming a solution with either 6% CHO or a placebo (PLA) 
      equivalent at 3 ml kg(-1) every 20 min. Serum interleukin-6 (IL-6), free 
      hemoglobin (Hb), haptoglobin (Hp), hepcidin and iron parameters were assessed 
      throughout the post-run recovery period. Serum iron and IL-6 were significantly 
      elevated immediately post-run in both CHO and PLA (p </= 0.05), with no differences 
      between trials. Serum-free Hb increased and Hp decreased significantly 
      immediately post-run in both conditions (p </= 0.05). Serum soluble transferrin 
      receptor levels were significantly below the baseline at 3 and 24 h post-run in 
      both conditions (p </= 0.05). Serum hepcidin concentration recorded 3 h post-run in 
      both conditions was significantly elevated (p </= 0.05), and had returned to the 
      baseline by 24 h post-run (p </= 0.05). The use of a 6% CHO solution at 3 ml kg(-1) 
      20 min(-1) during endurance running did not attenuate the inflammatory response 
      and subsequent increase in serum hepcidin levels during the post-run recovery 
      period.
FAU - Sim, Marc
AU  - Sim M
AD  - School of Sport Science, Exercise and Health, The University of Western 
      Australia, 35 Stirling Hwy, Crawley, WA 6009, Australia. 
      simm08@student.uwa.edu.au
FAU - Dawson, Brian
AU  - Dawson B
FAU - Landers, Grant
AU  - Landers G
FAU - Wiegerinck, Erwin T
AU  - Wiegerinck ET
FAU - Swinkels, Dorine W
AU  - Swinkels DW
FAU - Townsend, Mary-Anne
AU  - Townsend MA
FAU - Trinder, Debbie
AU  - Trinder D
FAU - Peeling, Peter
AU  - Peeling P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110916
PL  - Germany
TA  - Eur J Appl Physiol
JT  - European journal of applied physiology
JID - 100954790
RN  - 0 (Antimicrobial Cationic Peptides)
RN  - 0 (Cytokines)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (HAMP protein, human)
RN  - 0 (Hepcidins)
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - Antimicrobial Cationic Peptides/*blood
MH  - Cytokines/blood
MH  - Dietary Carbohydrates/administration & dosage/*pharmacology
MH  - Exercise/*physiology
MH  - Exercise Test
MH  - Hemolysis
MH  - Hepcidins
MH  - Humans
MH  - Inflammation/*blood
MH  - Iron/*blood
MH  - Male
MH  - Physical Endurance/physiology
MH  - Running/*physiology
MH  - Young Adult
EDAT- 2011/09/17 06:00
MHDA- 2013/05/02 06:00
CRDT- 2011/09/17 06:00
PHST- 2010/11/21 00:00 [received]
PHST- 2011/08/27 00:00 [accepted]
PHST- 2011/09/17 06:00 [entrez]
PHST- 2011/09/17 06:00 [pubmed]
PHST- 2013/05/02 06:00 [medline]
AID - 10.1007/s00421-011-2156-0 [doi]
PST - ppublish
SO  - Eur J Appl Physiol. 2012 May;112(5):1889-98. doi: 10.1007/s00421-011-2156-0. Epub 
      2011 Sep 16.