PMID- 21922295
OWN - NLM
STAT- MEDLINE
DCOM- 20120821
LR  - 20221207
IS  - 1573-4927 (Electronic)
IS  - 0006-2928 (Linking)
VI  - 50
IP  - 1-2
DP  - 2012 Feb
TI  - Hardy-Weinberg disequilibrium of the IL-18 C-607A SNP suggesting selective 
      advantage of heterozygotes.
PG  - 63-72
LID - 10.1007/s10528-011-9459-z [doi]
AB  - Interleukin-18 (IL-18) plays a key role in autoimmune, inflammatory, and 
      infectious diseases. The IL-18 gene contains a C to A single nucleotide 
      polymorphism (SNP) at position -607 (C-607A) within the promoter region, which 
      was found to affect the promoter activity and subsequently the protein level of 
      IL-18. We investigated this SNP in a group of healthy Singaporeans and found that 
      CA was the most common genotype and the C allele was more prevalent than the A 
      allele, which was not always the case in other ethnic groups. In addition, 
      Singaporean Chinese were significantly different from Singaporean Indians in both 
      allelic and genotypic distributions. Furthermore, significant deviations from 
      Hardy-Weinberg equilibrium of this SNP were found in all three ethnic groups 
      studied (Chinese, Indians, and Malays) and also in other published literature, 
      suggesting that heterozygotes of this IL-18 C-607A SNP may have certain selective 
      advantages.
FAU - Chen, Chuan Fei
AU  - Chen CF
AD  - Natural Sciences and Science Education, National Institute of Education, Nanyang 
      Technological University, 1 Nanyang Walk, Singapore, 637616, Singapore.
FAU - Gan, Yik Yuen
AU  - Gan YY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110916
PL  - United States
TA  - Biochem Genet
JT  - Biochemical genetics
JID - 0126611
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Asian People/genetics
MH  - Ethnicity/*genetics
MH  - *Heterozygote
MH  - Humans
MH  - Interleukin-18/*genetics
MH  - Models, Genetic
MH  - *Polymorphism, Single Nucleotide
MH  - Singapore/ethnology
EDAT- 2011/09/17 06:00
MHDA- 2012/08/22 06:00
CRDT- 2011/09/17 06:00
PHST- 2010/05/22 00:00 [received]
PHST- 2011/05/25 00:00 [accepted]
PHST- 2011/09/17 06:00 [entrez]
PHST- 2011/09/17 06:00 [pubmed]
PHST- 2012/08/22 06:00 [medline]
AID - 10.1007/s10528-011-9459-z [doi]
PST - ppublish
SO  - Biochem Genet. 2012 Feb;50(1-2):63-72. doi: 10.1007/s10528-011-9459-z. Epub 2011 
      Sep 16.