PMID- 21923686
OWN - NLM
STAT- MEDLINE
DCOM- 20120216
LR  - 20221207
IS  - 1523-5378 (Electronic)
IS  - 1083-4389 (Print)
IS  - 1083-4389 (Linking)
VI  - 16
IP  - 5
DP  - 2011 Oct
TI  - Effects of myeloid differentiation primary response gene 88 (MyD88) activation on 
      Helicobacter infection in vivo and induction of a Th17 response.
PG  - 398-404
LID - 10.1111/j.1523-5378.2011.00861.x [doi]
AB  - BACKGROUND: Helicobacter pylori is a spiral-shaped Gram-negative microaerophilic 
      bacterium associated with a number of gastrointestinal disorders, including 
      gastritis, peptic ulcers, and gastric cancer. Several studies have implicated a 
      Th17 response as a key to protective immunity against Helicobacter. MATERIALS AND 
      METHODS: Wild type (WT) and MyD88-deficient (MyD88(-/-)) mice in the C57BL/6 
      background were infected with H. felis for 6 and 25 weeks and colonization 
      density and host response evaluated. Real-time PCR was used to determine the 
      expression of cytokines and antimicrobial peptides in the gastric tissue of mice. 
      RESULTS: mRNA expression levels of the Th17 cytokines interleukin-17A (IL-17A) 
      and IL-22 were markedly up-regulated in WT compared with MyD88(-/-) mice both at 
      6 and at 25 weeks in response to infection with H. felis, indicating that 
      induction of Th17 responses depends on MyD88 signaling. Furthermore, reduction in 
      the expression of Th17-dependent intestinal antimicrobial peptide lipocalin-2 was 
      linked with increased bacterial burden in the absence of MyD88 signaling. 
      CONCLUSION: We provide evidence showing that MyD88-dependent signaling is 
      required for the host to induce a Th17 response for the control of Helicobacter 
      infection.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Obonyo, Marygorret
AU  - Obonyo M
AD  - Department of Medicine, San Diego School of Medicine, University of California, 
      La Jolla, 92093-0640, USA. mobonyo@ucsd.edu
FAU - Rickman, Barry
AU  - Rickman B
FAU - Guiney, Donald G
AU  - Guiney DG
LA  - eng
GR  - R24 DK080506/DK/NIDDK NIH HHS/United States
GR  - U54 CA132379/CA/NCI NIH HHS/United States
GR  - U54 CA132384/CA/NCI NIH HHS/United States
GR  - DK080506/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Helicobacter
JT  - Helicobacter
JID - 9605411
RN  - 0 (Acute-Phase Proteins)
RN  - 0 (Antimicrobial Cationic Peptides)
RN  - 0 (Cathelicidins)
RN  - 0 (Cytokines)
RN  - 0 (Defensins)
RN  - 0 (Lipocalin-2)
RN  - 0 (Lipocalins)
RN  - 0 (Myd88 protein, mouse)
RN  - 0 (Myeloid Differentiation Factor 88)
RN  - 0 (Oncogene Proteins)
RN  - 126469-30-5 (Lcn2 protein, mouse)
SB  - IM
MH  - Acute-Phase Proteins/metabolism
MH  - Animals
MH  - Antimicrobial Cationic Peptides
MH  - Cathelicidins/metabolism
MH  - Cytokines/metabolism
MH  - Defensins/metabolism
MH  - Gastric Mucosa/metabolism
MH  - Helicobacter Infections/genetics/*immunology
MH  - Helicobacter felis/*immunology
MH  - Lipocalin-2
MH  - Lipocalins/metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Myeloid Differentiation Factor 88/genetics/*physiology
MH  - Oncogene Proteins/metabolism
MH  - Signal Transduction/immunology
MH  - Th17 Cells/*immunology
PMC - PMC3535435
MID - NIHMS294791
EDAT- 2011/09/20 06:00
MHDA- 2012/02/18 06:00
PMCR- 2013/01/03
CRDT- 2011/09/20 06:00
PHST- 2011/09/20 06:00 [entrez]
PHST- 2011/09/20 06:00 [pubmed]
PHST- 2012/02/18 06:00 [medline]
PHST- 2013/01/03 00:00 [pmc-release]
AID - 10.1111/j.1523-5378.2011.00861.x [doi]
PST - ppublish
SO  - Helicobacter. 2011 Oct;16(5):398-404. doi: 10.1111/j.1523-5378.2011.00861.x.